A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn

Glenda M. Millard; Eunike C. McGowan; Brett Wilson; Jacqui R. Martin; Michaela Spooner; Scott Morris; Ray Farley; Simon James; Yew-Wah Liew; Elizna M. Schoeman; Melinda M. Dean; Robert L. Flower; Catherine A. Hyland; Tanya Powley; David Roxby

doi:10.1111/trf.14562

A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn

Glenda M. Millard, Eunike C. McGowan, Brett Wilson, Jacqui R. Martin, Michaela Spooner, Scott Morris, Ray Farley, Simon James, Yew-Wah Liew, Elizna M. Schoeman, Melinda M. Dean, Robert L. Flower, Catherine A. Hyland, Tanya Powley, David Roxby

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A male infant born at 29 weeks presented with a severe case of hemolytic disease of the fetus and newborn (HDFN) (cord blood direct anti-globulin test 41, hemoglobin 45 g/L with cardiac failure, pleural effusion, and generalized edema). Two exchange and four top-up transfusions were required. The maternal antibody was reactive with paternal red blood cells (RBCs). Later testing revealed that the antibody reacted with RBCs from four additional members of the paternal family. Extensive testing excluded clinically relevant RBC antibodies but failed to reveal a specificity for this antibody. To guide further investigation, specimens from the family (n510) were submitted for blood group genetic studies.

Original language	English
Pages (from-to)	1320-1322
Number of pages	3
Journal	TRANSFUSION
Volume	58
Issue number	5
Early online date	2018
DOIs	https://doi.org/10.1111/trf.14562
Publication status	Published - May 2018
Externally published	Yes

Keywords

low-frequency antigen
Augustine blood group system
hemolytic disease

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Millard, G. M., McGowan, E. C., Wilson, B., Martin, J. R., Spooner, M., Morris, S., Farley, R., James, S., Liew, Y.-W., Schoeman, E. M., Dean, M. M., Flower, R. L., Hyland, C. A., Powley, T., & Roxby, D. (2018). A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn. TRANSFUSION, 58(5), 1320-1322. https://doi.org/10.1111/trf.14562

@article{f262c022c1814abcb72c3c42c57f1de4,

title = "A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn",

abstract = "A male infant born at 29 weeks presented with a severe case of hemolytic disease of the fetus and newborn (HDFN) (cord blood direct anti-globulin test 41, hemoglobin 45 g/L with cardiac failure, pleural effusion, and generalized edema). Two exchange and four top-up transfusions were required. The maternal antibody was reactive with paternal red blood cells (RBCs). Later testing revealed that the antibody reacted with RBCs from four additional members of the paternal family. Extensive testing excluded clinically relevant RBC antibodies but failed to reveal a specificity for this antibody. To guide further investigation, specimens from the family (n510) were submitted for blood group genetic studies.",

keywords = "low-frequency antigen, Augustine blood group system, hemolytic disease",

author = "Millard, {Glenda M.} and McGowan, {Eunike C.} and Brett Wilson and Martin, {Jacqui R.} and Michaela Spooner and Scott Morris and Ray Farley and Simon James and Yew-Wah Liew and Schoeman, {Elizna M.} and Dean, {Melinda M.} and Flower, {Robert L.} and Hyland, {Catherine A.} and Tanya Powley and David Roxby",

year = "2018",

month = may,

doi = "10.1111/trf.14562",

language = "English",

volume = "58",

pages = "1320--1322",

journal = "TRANSFUSION",

issn = "0041-1132",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

}

Millard, GM, McGowan, EC, Wilson, B, Martin, JR, Spooner, M, Morris, S, Farley, R, James, S, Liew, Y-W, Schoeman, EM, Dean, MM, Flower, RL, Hyland, CA, Powley, T & Roxby, D 2018, 'A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn', TRANSFUSION, vol. 58, no. 5, pp. 1320-1322. https://doi.org/10.1111/trf.14562

TY - JOUR

T1 - A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn

AU - Millard, Glenda M.

AU - McGowan, Eunike C.

AU - Wilson, Brett

AU - Martin, Jacqui R.

AU - Spooner, Michaela

AU - Morris, Scott

AU - Farley, Ray

AU - James, Simon

AU - Liew, Yew-Wah

AU - Schoeman, Elizna M.

AU - Dean, Melinda M.

AU - Flower, Robert L.

AU - Hyland, Catherine A.

AU - Powley, Tanya

AU - Roxby, David

PY - 2018/5

Y1 - 2018/5

N2 - A male infant born at 29 weeks presented with a severe case of hemolytic disease of the fetus and newborn (HDFN) (cord blood direct anti-globulin test 41, hemoglobin 45 g/L with cardiac failure, pleural effusion, and generalized edema). Two exchange and four top-up transfusions were required. The maternal antibody was reactive with paternal red blood cells (RBCs). Later testing revealed that the antibody reacted with RBCs from four additional members of the paternal family. Extensive testing excluded clinically relevant RBC antibodies but failed to reveal a specificity for this antibody. To guide further investigation, specimens from the family (n510) were submitted for blood group genetic studies.

AB - A male infant born at 29 weeks presented with a severe case of hemolytic disease of the fetus and newborn (HDFN) (cord blood direct anti-globulin test 41, hemoglobin 45 g/L with cardiac failure, pleural effusion, and generalized edema). Two exchange and four top-up transfusions were required. The maternal antibody was reactive with paternal red blood cells (RBCs). Later testing revealed that the antibody reacted with RBCs from four additional members of the paternal family. Extensive testing excluded clinically relevant RBC antibodies but failed to reveal a specificity for this antibody. To guide further investigation, specimens from the family (n510) were submitted for blood group genetic studies.

KW - low-frequency antigen

KW - Augustine blood group system

KW - hemolytic disease

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U2 - 10.1111/trf.14562

DO - 10.1111/trf.14562

M3 - Article

SN - 0041-1132

VL - 58

SP - 1320

EP - 1322

JO - TRANSFUSION

JF - TRANSFUSION

IS - 5

ER -

A proposed new low-frequency antigen in the Augustine blood group system associated with a severe case of hemolytic disease of the fetus and newborn

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Keywords

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