A Prospective Study of the Value of Monitoring Heparin Treatment with the Activated Partial Thromboplastin Time

Dilip Basu, Alexander Gallus, Jack Hirsh, John Cade

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482 Citations (Scopus)

Abstract

Two hundred and thirty-four patients treated with continuous intravenous infusions of heparin were studied prospectively to seek a relation between the activated partial thromboplastin time (APTT) and recurrent venous thromboembolism or bleeding during treatment. One hundred and sixty-two patients were treated for venous thromboembolism and the remaining 72 for other diseases. The heparin dose was adjusted to keep the APTT between 1 1/2 and 2 1/2 times control levels. The five patients with venous thromboembolism in whom recurrence developed had a significantly lower APTT than patients without recurrence even though they received similar amounts of heparin. No recurrence developed in any patient with a mean APTT within the therapeutic range. Bleeding occurred in 19 patients whose mean heparin dose and APTT were similar to those of patients without bleeding. Thus, recurrence of venous thromboembolism during heparin treatment appears to be rare if the APTT is prolonged to 1 1/2 times or more control values at all times.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalNew England Journal of Medicine
Volume287
Issue number7
DOIs
Publication statusPublished - 17 Aug 1972
Externally publishedYes

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