TY - JOUR
T1 - A Rat Model of Bacterial Keratitis
T2 - Effect of Antibiotics and Corticosteroid
AU - Badenoch, Paul R.
AU - Hay, Gregory J.
AU - Mcdonald, Peter J.
AU - Coster, Douglas J.
PY - 1985/5
Y1 - 1985/5
N2 - A model of bacterial keratitis in rats was developed to quantify the effect of antibiotics and corticosteroid on the infective process. Corneas were inoculated with Staphylococcus aureus, Pseudomonas aeruginosa or Streptococcus pneumoniae The natural history of infection with these organisms was determined. Groups of animals received topical antibiotics and prednisolone acetate. The effect of treatment on the number of leukocytes and viable bacteria in the corneas was determined. Prednisolone did not influence the effect of the antibiotics; however, steroid treatment alone increased the pseudomonad count as much as 20-fold above the count in untreated eyes. In general, both the antibiotic and steroid treatments were more successful when begun eight hours after infection than when begun at 24 hours. A 1% gentamicin sulfate preparation proved effective against each of the infections, including a pneumococcal strain considered resistant on the basis of in vitro tests.
AB - A model of bacterial keratitis in rats was developed to quantify the effect of antibiotics and corticosteroid on the infective process. Corneas were inoculated with Staphylococcus aureus, Pseudomonas aeruginosa or Streptococcus pneumoniae The natural history of infection with these organisms was determined. Groups of animals received topical antibiotics and prednisolone acetate. The effect of treatment on the number of leukocytes and viable bacteria in the corneas was determined. Prednisolone did not influence the effect of the antibiotics; however, steroid treatment alone increased the pseudomonad count as much as 20-fold above the count in untreated eyes. In general, both the antibiotic and steroid treatments were more successful when begun eight hours after infection than when begun at 24 hours. A 1% gentamicin sulfate preparation proved effective against each of the infections, including a pneumococcal strain considered resistant on the basis of in vitro tests.
UR - http://www.scopus.com/inward/record.url?scp=0021798399&partnerID=8YFLogxK
U2 - 10.1001/archopht.1985.01050050110028
DO - 10.1001/archopht.1985.01050050110028
M3 - Article
C2 - 3843063
AN - SCOPUS:0021798399
VL - 103
SP - 718
EP - 722
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
SN - 0003-9950
IS - 5
ER -