A retinal endothelial cell barrier is disrupted by direct contact with retinal Müller glial cells in vitro

Cameron D. Haydinger; Yuefang Ma; Justine R. Smith

doi:10.1111/ceo.14442

A retinal endothelial cell barrier is disrupted by direct contact with retinal Müller glial cells in vitro

Cameron D. Haydinger, Yuefang Ma, Justine R. Smith

Research output: Contribution to journal › Letter › peer-review

Abstract

The inner blood-retinal barrier restricts passage of solutes and microbes between the retinal vasculature and interstitial space, protecting the neural retina. This barrier is based at the level of the retinal endothelial cells (RECs), but it is influenced by supporting cells. Retinal Müller glial cells (RMGCs) are the most abundant glia in the retina. They surround the retinal vasculature, and during disease, breaches in the endothelial basement membrane bring them into direct contact with RECs.

We aimed to develop a model for investigating interactions between human RECs and RMGCs that might contribute to blood-retinal barrier breakdown...

Original language	English
Number of pages	4
Journal	Clinical and Experimental Ophthalmology
DOIs	https://doi.org/10.1111/ceo.14442
Publication status	E-pub ahead of print - 1 Oct 2024

Keywords

retinal endothelial cells
cell membranes
retinal vasculature

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abstract = "The inner blood-retinal barrier restricts passage of solutes and microbes between the retinal vasculature and interstitial space, protecting the neural retina. This barrier is based at the level of the retinal endothelial cells (RECs), but it is influenced by supporting cells. Retinal M{\"u}ller glial cells (RMGCs) are the most abundant glia in the retina. They surround the retinal vasculature, and during disease, breaches in the endothelial basement membrane bring them into direct contact with RECs.We aimed to develop a model for investigating interactions between human RECs and RMGCs that might contribute to blood-retinal barrier breakdown...",

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AU - Haydinger, Cameron D.

AU - Ma, Yuefang

AU - Smith, Justine R.

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Y1 - 2024/10/1

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AB - The inner blood-retinal barrier restricts passage of solutes and microbes between the retinal vasculature and interstitial space, protecting the neural retina. This barrier is based at the level of the retinal endothelial cells (RECs), but it is influenced by supporting cells. Retinal Müller glial cells (RMGCs) are the most abundant glia in the retina. They surround the retinal vasculature, and during disease, breaches in the endothelial basement membrane bring them into direct contact with RECs.We aimed to develop a model for investigating interactions between human RECs and RMGCs that might contribute to blood-retinal barrier breakdown...

KW - retinal endothelial cells

KW - cell membranes

KW - retinal vasculature

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SN - 1442-6404

JO - Clinical and Experimental Ophthalmology

JF - Clinical and Experimental Ophthalmology

ER -

A retinal endothelial cell barrier is disrupted by direct contact with retinal Müller glial cells in vitro

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