A review of therapeutic agents for breast cancer with potentially radiosensitizing properties

Zhongwei Zhang; David Lim; Zhihui Feng

doi:10.1016/j.radmp.2024.03.002

A review of therapeutic agents for breast cancer with potentially radiosensitizing properties

Zhongwei Zhang, David Lim, Zhihui Feng

Research output: Contribution to journal › Review article › peer-review

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Abstract

Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and widely used in clinical practice. Potential limitations with radiotherapy include treatment resistance, side effects, and complications caused by high doses of irradiation. The search has been on to locate an efficacious radiosensitizer. This review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.

Original language	English
Pages (from-to)	75-82
Number of pages	8
Journal	Radiation Medicine and Protection
Volume	5
Issue number	2
Early online date	13 Mar 2024
DOIs	https://doi.org/10.1016/j.radmp.2024.03.002
Publication status	Published - Jun 2024
Externally published	Yes

Keywords

Breast cancer
Radiosensitizer
Radiotherapy
Therapeutic agents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radmp.2024.03.002Licence: CC BY-NC-ND

Final published versionFinal published version, 662 KBLicence: CC BY-NC-ND

Cite this

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abstract = "Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and widely used in clinical practice. Potential limitations with radiotherapy include treatment resistance, side effects, and complications caused by high doses of irradiation. The search has been on to locate an efficacious radiosensitizer. This review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.",

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AU - Lim, David

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N2 - Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and widely used in clinical practice. Potential limitations with radiotherapy include treatment resistance, side effects, and complications caused by high doses of irradiation. The search has been on to locate an efficacious radiosensitizer. This review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.

AB - Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and widely used in clinical practice. Potential limitations with radiotherapy include treatment resistance, side effects, and complications caused by high doses of irradiation. The search has been on to locate an efficacious radiosensitizer. This review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.

KW - Breast cancer

KW - Radiosensitizer

KW - Radiotherapy

KW - Therapeutic agents

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A review of therapeutic agents for breast cancer with potentially radiosensitizing properties

Abstract

Keywords

UN SDGs

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