A rigorous approach to pairwise distance analysis of a protein family via multi-dimensional scaling and its application to the genealogy of squalene synthase paralogues of green algae. from Algorithms to Applications 2020" conference

Robert Moore, Michael Barnathan, Brian Fristensky, Yan Li, Greg Knowles, Paul Gardner-Stephen, Angelo Bueti, Peter Anderson, Jian Qin, Andy Ball

Research output: Contribution to journalMeeting Abstractpeer-review

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Abstract

Gene duplication resulting in paralogues is an imperfectly understood process in terms of the order of duplications facilitating the evolution of new functions. An example is the Squalene Synthase-Like (SSL) gene family of the oil-bearing green alga Botryococcus braunii race B. Squalene synthases combine two half reactions of catalysis, being the formation of presqualene disphosphate (PSPP) and then the subsequent synthesis of a triterpenoid, in this case squalene. It was previously established that the SSL paralogues have separated these two half reactions. From 'Selected abstracts of “Bioinformatics: from Algorithms to Applications 2020” conference'
Original languageEnglish
Article number567
Pages (from-to)4-5
Number of pages2
JournalBMC Bioinformatics
Volume21
Issue numberSuppl 20
DOIs
Publication statusPublished - 17 Dec 2020

Keywords

  • Gene duplication
  • Squalene Synthase-Like (SSL
  • Green algae
  • squalene synthases
  • BSS
  • botryocccene synthesis

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