A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

N. R. Sims; C. C. Bernard; L. Horvath; I. R. Mackay; P. R. Carnegie

doi:10.1007/978-1-4684-2514-7_29

A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

N. R. Sims, C. C. Bernard, L. Horvath, I. R. Mackay, P. R. Carnegie

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Abstract

Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.

Original language	English
Pages (from-to)	411-422
Number of pages	12
Journal	Advances in Experimental Medicine and Biology
Volume	100
DOIs	https://doi.org/10.1007/978-1-4684-2514-7_29
Publication status	Published - 1978
Externally published	Yes

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AU - Mackay, I. R.

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AB - Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.

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A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

Abstract

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