A serial study of gastric emptying in anorexia nervosa and bulimia

G. I. Szmukler, G. P. Young, M. Lichtenstein, J. T. Andrews

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To determine the natural history of delayed gastric emptying of solid foods in anorexia nervosa (AN), gastric emptying was assessed by scintigraphy in 20 consecutive inpatients; eight had restrictive AN, ten had both AN and bulimia nervosa (BN), and two BN alone. Initial gastric half‐emptying time (HET) exceeded 110 min (the upper limit of normal for the laboratory) in 16; their body mass index ranged from 11.7 to 18.1. HET showed a significant negative correlation with body mass (r = 0.71; p<0.001) but not age, duration of illness or use of psychotropic medication. Fourteen patients with prolonged emptying were retested; HET improved in nine of 12 retested at one month (p= 0.0005) but none showed a change in the lag phase of emptying. All four patients retested a further one to two months later achieved a HET < 110 min. Fourteen patients reached a body mass index of 16.3 during treatment and HET improved to better than 110 min in all but one of these. However, normalisation occurred while body mass was still subnormal (<20.3) and with amenorrhea still present. This study shows that delayed gastric emptying in AN improves quite rapidly as feeding recommences; thus the motility disturbance is secondary to restriction in food intake and is not fundamental to the disorder.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalAustralian and New Zealand Journal of Medicine
Volume20
Issue number3
DOIs
Publication statusPublished - Jun 1990
Externally publishedYes

Keywords

  • Anorexia nervosa
  • bulimia nervosa
  • fasting
  • gastric emptying
  • starvation

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