A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz, Jabbar Khalafy, Nader Pesyan, Rolf Prager

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

    Original languageEnglish
    Pages (from-to)507-510
    Number of pages4
    JournalAustralian Journal of Chemistry
    Volume63
    Issue number3
    DOIs
    Publication statusPublished - 2010

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