A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz; Jabbar Khalafy; Nader Pesyan; Rolf Prager

doi:10.1071/CH09569

A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

Mehdi Rimaz, Jabbar Khalafy, Nader Pesyan, Rolf Prager

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	Australian Journal of Chemistry
Volume	63
Issue number	3
DOIs	https://doi.org/10.1071/CH09569
Publication status	Published - 2010

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title = "A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors",

abstract = "Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.",

author = "Mehdi Rimaz and Jabbar Khalafy and Nader Pesyan and Rolf Prager",

year = "2010",

doi = "10.1071/CH09569",

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volume = "63",

pages = "507--510",

journal = "Australian Journal of Chemistry",

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T1 - A Simple One-Pot, Three Component Synthesis of 3-Arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their Sulfur Analogues as Potential Monoamine Oxidase Inhibitors

AU - Rimaz, Mehdi

AU - Khalafy, Jabbar

AU - Pesyan, Nader

AU - Prager, Rolf

PY - 2010

Y1 - 2010

N2 - Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

AB - Several new 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-5-oxo-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones have been synthesized by a three-component reaction of barbituric acid or thiobarbituric acid with arylglyoxals in the presence of a catalytic amount of pyridine and hydrazine hydrate at room temperature in water.

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U2 - 10.1071/CH09569

DO - 10.1071/CH09569

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EP - 510

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

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