A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics

Yuanyuan Li, Mubin He, Zeming Liu, Clarence Chuah, Youhong Tang, Yanhong Duo, Ben Zhong Tang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The pursuit of phototheranostic agents with near-infrared II (NIR-II) emission, high photothermal conversion efficiency (PCE) and the robust generation of reactive oxygen species (ROS) in the aggregated state is always in high demand but remains a big challenge. Herein, we report a simple strategy to endow molecules with NIR-II imaging and photothermal therapy (PTT)/photodynamic therapy (PDT) abilities by equipping NIR-II aggregation-induced emission luminogens (AIEgens) with the cationic trimethylammonium unit, named as TDTN+. The resultant TDTN+ species can self-assemble into nanoparticles, which exhibit a maximum emission at ∼1052 nm, a high PCE (66.7%), type I and type II ROS generation and a mitochondria-targeting ability, simultaneously. The TDTN+ can realize brain imaging with bright fluorescence and an effective tumor killing effect. Overall, this work presents an innovative design strategy to develop multimodality phototheranostic agents.

Original languageEnglish
Pages (from-to)2700-2705
Number of pages6
JournalJournal of materials chemistry. B
Issue number12
Early online date17 Feb 2023
Publication statusPublished - 28 Mar 2023


  • phototheranostic agents
  • NIR-II imaging
  • photothermal therapy (PTT)
  • photodynamic therapy (PDT)


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