Dissociated sympathetic neurons in culture have been used to demonstrate the presence of trophic activity within the densely innervated expansor secundariorum smooth muscle of the avian wing. The activity is heat unstable and non-dialysable, suggesting that a macromolecular species is responsible. As relatively high concentrations of the activity are present, the use of this muscle is suggested for study of the regulation and characterization of trophic molecules relevant to the sympathetic nervous system.
- dissociated neurons
- expansor secundariorum