A systematic review and meta-analysis of paraoxonase-1 activity in asthma

Stefania Bassu, Arduino A. Mangoni, Dario Argiolas, Ciriaco Carru, Pietro Pirina, Alessandro G. Fois, Angelo Zinellu

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Human serum paraoxonase-1 (PON-1) is a critical antioxidant defence system against lipid oxidation. Decreased PON-1 activity has been associated with systemic oxidative stress in several disease states. We conducted a systematic review and meta-analysis of plasma/serum concentrations of PON-1 in asthma, a chronic inflammatory airway disease. The electronic databases PubMed, Web of Science, Scopus and Google Scholar were searched from inception to February 2022. In total, 8 studies in 355 asthmatic patients and 289 healthy controls were included in the meta-analysis. Serum PON-1 concentrations were significantly lower in asthmatic patients (SMD = −1.58, 95% CI −2.53 to −0.63; p = 0.001). The pooled SMD values were not substantially altered in sensitivity analysis. There was no publication bias. There were non-significant differences in PON-1 concentrations in patients with severe vs. mild-to-moderate asthma (SMD = − 0.39, 95% CI − 1.00 to 0.22, p = 0.21). Our meta-analysis has shown that serum PON-1 concentrations are significantly lower in patients with asthma, suggesting the presence of an impaired antioxidant defense in this group.

Original languageEnglish
Number of pages8
Early online date7 Nov 2022
Publication statusE-pub ahead of print - 7 Nov 2022


  • Chronic
  • Disease
  • Inflammation
  • Oxidative stress
  • PON-1


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