A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways

Joel Castro; Andrea M. Harrington; TinaMarie Lieu; Sonia Garcia-Caraballo; Jessica Maddern; Tracey O'Donnell; Luke Grundy; Daniel P. Poole; Nigel W. Bunnett; Stuart M. Brierley

doi:10.1016/S0016-5085(15)32505-1

A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways

Joel Castro, Andrea M. Harrington, TinaMarie Lieu, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O'Donnell, Luke Grundy, Daniel P. Poole, Nigel W. Bunnett, Stuart M. Brierley

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Itch, like pain, is a major protective mechanism. Itch removes irritants from the skin, whilst pain allows withdrawal or avoidance of tissue damage. Painful and pruritogenic stimuli activate the peripheral endings of primary afferents that innervate second order neurons within the spinal cord. Whilst pain arises from both the skin and viscera; we investigated whether ‘itch-specific' pruritogenic mechanisms also have functions within visceral pathways.

Original language	English
Article number	Mo1876
Pages (from-to)	S-733
Number of pages	1
Journal	Gastroenterology
Volume	148
Issue number	4 Supplement 1
DOIs	https://doi.org/10.1016/S0016-5085(15)32505-1
Publication status	Published - 2015
Event	Digestive Disease Week 2015 - Washington DC, United States Duration: 16 May 2015 → 19 May 2015

Keywords

itch
visceral representation
pruritogenic stimuli
Colonic sensory pathways
spinal cord
visceral pathways

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Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., Poole, D. P., Bunnett, N. W., & Brierley, S. M. (2015). A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways. Gastroenterology, 148(4 Supplement 1), S-733. [Mo1876]. https://doi.org/10.1016/S0016-5085(15)32505-1

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title = "A Visceral Representation of Itch: Identification {\textquoteleft}Itch-Specific{\textquoteright} Pruritogenic Mechanisms Within Colonic Sensory Pathways",

abstract = "Itch, like pain, is a major protective mechanism. Itch removes irritants from the skin, whilst pain allows withdrawal or avoidance of tissue damage. Painful and pruritogenic stimuli activate the peripheral endings of primary afferents that innervate second order neurons within the spinal cord. Whilst pain arises from both the skin and viscera; we investigated whether {\textquoteleft}itch-specific' pruritogenic mechanisms also have functions within visceral pathways.",

keywords = "itch, visceral representation, pruritogenic stimuli, Colonic sensory pathways, spinal cord, visceral pathways",

author = "Joel Castro and Harrington, {Andrea M.} and TinaMarie Lieu and Sonia Garcia-Caraballo and Jessica Maddern and Tracey O'Donnell and Luke Grundy and Poole, {Daniel P.} and Bunnett, {Nigel W.} and Brierley, {Stuart M.}",

year = "2015",

doi = "10.1016/S0016-5085(15)32505-1",

language = "English",

volume = "148",

pages = "S--733",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Co.",

number = "4 Supplement 1",

note = "Digestive Disease Week 2015 ; Conference date: 16-05-2015 Through 19-05-2015",

}

Castro, J , Harrington, AM, Lieu, T, Garcia-Caraballo, S, Maddern, J, O'Donnell, T, Grundy, L, Poole, DP, Bunnett, NW & Brierley, SM 2015, 'A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways', Gastroenterology, vol. 148, no. 4 Supplement 1, Mo1876, pp. S-733. https://doi.org/10.1016/S0016-5085(15)32505-1

TY - JOUR

T1 - A Visceral Representation of Itch

T2 - Digestive Disease Week 2015

AU - Castro, Joel

AU - Harrington, Andrea M.

AU - Lieu, TinaMarie

AU - Garcia-Caraballo, Sonia

AU - Maddern, Jessica

AU - O'Donnell, Tracey

AU - Grundy, Luke

AU - Poole, Daniel P.

AU - Bunnett, Nigel W.

AU - Brierley, Stuart M.

PY - 2015

Y1 - 2015

N2 - Itch, like pain, is a major protective mechanism. Itch removes irritants from the skin, whilst pain allows withdrawal or avoidance of tissue damage. Painful and pruritogenic stimuli activate the peripheral endings of primary afferents that innervate second order neurons within the spinal cord. Whilst pain arises from both the skin and viscera; we investigated whether ‘itch-specific' pruritogenic mechanisms also have functions within visceral pathways.

AB - Itch, like pain, is a major protective mechanism. Itch removes irritants from the skin, whilst pain allows withdrawal or avoidance of tissue damage. Painful and pruritogenic stimuli activate the peripheral endings of primary afferents that innervate second order neurons within the spinal cord. Whilst pain arises from both the skin and viscera; we investigated whether ‘itch-specific' pruritogenic mechanisms also have functions within visceral pathways.

KW - itch

KW - visceral representation

KW - pruritogenic stimuli

KW - Colonic sensory pathways

KW - spinal cord

KW - visceral pathways

U2 - 10.1016/S0016-5085(15)32505-1

DO - 10.1016/S0016-5085(15)32505-1

M3 - Meeting Abstract

SN - 0016-5085

VL - 148

SP - S-733

JO - Gastroenterology

JF - Gastroenterology

IS - 4 Supplement 1

M1 - Mo1876

Y2 - 16 May 2015 through 19 May 2015

ER -

A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways

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Keywords

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