A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways

Joel Castro, Andrea M. Harrington, TinaMarie Lieu, Sonia Garcia-Caraballo, Jessica Maddern, Tracey O'Donnell, Luke Grundy, Daniel P. Poole, Nigel W. Bunnett, Stuart M. Brierley

    Research output: Contribution to journalMeeting Abstractpeer-review

    Abstract

    Itch, like pain, is a major protective mechanism. Itch removes irritants from the skin, whilst pain allows withdrawal or avoidance of tissue damage. Painful and pruritogenic stimuli activate the peripheral endings of primary afferents that innervate second order neurons within the spinal cord. Whilst pain arises from both the skin and viscera; we investigated whether ‘itch-specific' pruritogenic mechanisms also have functions within visceral pathways.
    Original languageEnglish
    Article numberMo1876
    Pages (from-to)S-733
    Number of pages1
    JournalGastroenterology
    Volume148
    Issue number4 Supplement 1
    DOIs
    Publication statusPublished - 2015
    EventDigestive Disease Week 2015 - Washington DC, United States
    Duration: 16 May 201519 May 2015

    Keywords

    • itch
    • visceral representation
    • pruritogenic stimuli
    • Colonic sensory pathways
    • spinal cord
    • visceral pathways

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