Abdominal vagal inputs to catecholamine neurons in the ventrolateral medulla

Z. J. Gieroba, J. P. Messenger, W. W. Blessing

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Stimulation of the abdominal vagus nerve increases arterial pressure and causes secretion of vasopressin. We have shown in rabbits that the arterial pressure increases are mediated by activation of barosensitive bulbospinal neurons in the C1 region of the rostral medulla. Secretion of vasopressin involves activation of neurons in the A1 region of the caudal ventrolateral medulla. Neuroanatomical studies with Fos indicate that approximately 50% of the C1 area cells are C1 neurons. Approximately 70% of the A1 area cells are A1 neurons. These neurons may mediate physiological responses occurring during abdominal malaise resulting from ingestion of toxins. Our discovery of a major excitatory input to A1 and C1 neurons from the abdominal vagus should prove useful in studies of the function of these neurons.

    Original languageEnglish
    Pages (from-to)237-250
    Number of pages14
    JournalClinical and Experimental Hypertension
    Volume17
    Issue number1-2
    DOIs
    Publication statusPublished - 1995

    Keywords

    • Abdominal vagus nerve
    • Arterial pressure
    • Fos
    • Nausea
    • Stomach
    • Vasopressin
    • Ventrolateral medulla
    • Vomiting

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