Abnormal stimulus processing in posttraumatic stress disorder

Alexander C. McFarlane, Darren Lee Weber, C. Richard Clark

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    181 Citations (Scopus)

    Abstract

    This study investigated event-related potential (ERP) indices of information processing in sufferers of posttraumatic stress disorder (PTSD). ERPs were obtained from 18 PTSD patients and 20 controls while they performed a target discrimination task requiring the detection of infrequent target tones from a background sequence of frequent and infrequent distractor tones. A delayed N2 and an attenuated P3 that failed to differentiate target from distractor tones indicated that patients had abnormal difficulty distinguishing task stimuli of differing relevance. It is proposed that this difficulty is reflected behaviorally in the slowed reaction time by patients to target stimuli and may underlie the disturbed concentration and memory impairments found in PTSD. It may also be related to dysfunction in central noradrenaline function, which has been shown to be both crucial in selective attention and abnormal in PTSD.

    Original languageEnglish
    Pages (from-to)311-320
    Number of pages10
    JournalBiological Psychiatry
    Volume34
    Issue number5
    DOIs
    Publication statusPublished - 1 Sep 1993

    Keywords

    • concentration
    • event-related potentials
    • evoked potentials
    • neurotransmission
    • noradrenaline
    • Posttraumatic stress disorder

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