Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice

Ranjay Chakraborty; Hanna Park; Erica Landis; Michael Bergen; Li He; Paul Iuvone; Machelle Pardue

Abstract

Purpose: We have previously shown that functional rod photoreceptors are critical to visually driven ocular growth in mice. In this study, we examined the contribution of cone mediated retinal pathways to normal refractive development and to visual form-deprivation (FD) in a mouse model lacking functional cone photoreceptors (Gnat2).

Methods: Refractive development of Gnat2and age-matched wild-type (WT) mice, were measured every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular FD in the right eye from 4 weeks of age using head-mounted diffuser goggles. Refraction, corneal curvature,and ocular biometrics were obtained using photorefraction, keratometry and spectral-domain optical coherence tomography.

Original language	English
Number of pages	2
Publication status	Published - Nov 2016
Externally published	Yes
Event	Academy 2016: Current State of Health Care and Research - Orlando, United States Duration: 9 Nov 2016 → …

Conference

Conference	Academy 2016
Country/Territory	United States
City	Orlando
Period	9/11/16 → …

Keywords

rod photoreceptors
cone mediated retinal pathways
mice
refractive development
visual form-deprivation (FD)

Access to Document

https://www.aaopt.org/detail/knowledge-base-article/absence-cone-mediated-retinal-pathways-increases-susceptibility-form-deprivation-myopia-miceLicence: In Copyright

Cite this

Chakraborty, R., Park, H., Landis, E., Bergen, M., He, L., Iuvone, P., & Pardue, M. (2016). Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice. Abstract from Academy 2016, Orlando, Florida, United States. https://www.aaopt.org/detail/knowledge-base-article/absence-cone-mediated-retinal-pathways-increases-susceptibility-form-deprivation-myopia-mice

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title = "Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice",

abstract = "Purpose: We have previously shown that functional rod photoreceptors are critical to visually driven ocular growth in mice. In this study, we examined the contribution of cone mediated retinal pathways to normal refractive development and to visual form-deprivation (FD) in a mouse model lacking functional cone photoreceptors (Gnat2). Methods: Refractive development of Gnat2and age-matched wild-type (WT) mice, were measured every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular FD in the right eye from 4 weeks of age using head-mounted diffuser goggles. Refraction, corneal curvature,and ocular biometrics were obtained using photorefraction, keratometry and spectral-domain optical coherence tomography.",

keywords = "rod photoreceptors, cone mediated retinal pathways, mice, refractive development, visual form-deprivation (FD)",

author = "Ranjay Chakraborty and Hanna Park and Erica Landis and Michael Bergen and Li He and Paul Iuvone and Machelle Pardue",

year = "2016",

month = nov,

language = "English",

note = "Academy 2016 : Current State of Health Care and Research ; Conference date: 09-11-2016",

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Chakraborty, R, Park, H, Landis, E, Bergen, M, He, L, Iuvone, P & Pardue, M 2016, 'Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice', Academy 2016, Orlando, United States, 9/11/16. <https://www.aaopt.org/detail/knowledge-base-article/absence-cone-mediated-retinal-pathways-increases-susceptibility-form-deprivation-myopia-mice>

TY - CONF

T1 - Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice

AU - Chakraborty, Ranjay

AU - Park, Hanna

AU - Landis, Erica

AU - Bergen, Michael

AU - He, Li

AU - Iuvone, Paul

AU - Pardue, Machelle

PY - 2016/11

Y1 - 2016/11

N2 - Purpose: We have previously shown that functional rod photoreceptors are critical to visually driven ocular growth in mice. In this study, we examined the contribution of cone mediated retinal pathways to normal refractive development and to visual form-deprivation (FD) in a mouse model lacking functional cone photoreceptors (Gnat2). Methods: Refractive development of Gnat2and age-matched wild-type (WT) mice, were measured every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular FD in the right eye from 4 weeks of age using head-mounted diffuser goggles. Refraction, corneal curvature,and ocular biometrics were obtained using photorefraction, keratometry and spectral-domain optical coherence tomography.

AB - Purpose: We have previously shown that functional rod photoreceptors are critical to visually driven ocular growth in mice. In this study, we examined the contribution of cone mediated retinal pathways to normal refractive development and to visual form-deprivation (FD) in a mouse model lacking functional cone photoreceptors (Gnat2). Methods: Refractive development of Gnat2and age-matched wild-type (WT) mice, were measured every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular FD in the right eye from 4 weeks of age using head-mounted diffuser goggles. Refraction, corneal curvature,and ocular biometrics were obtained using photorefraction, keratometry and spectral-domain optical coherence tomography.

KW - rod photoreceptors

KW - cone mediated retinal pathways

KW - mice

KW - refractive development

KW - visual form-deprivation (FD)

M3 - Abstract

T2 - Academy 2016

Y2 - 9 November 2016