Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice

Ranjay Chakraborty, Hanna Park, Erica Landis, Michael Bergen, Li He, Paul Iuvone, Machelle Pardue

Research output: Contribution to conferenceAbstract

Abstract

Purpose: We have previously shown that functional rod photoreceptors are critical to visually driven ocular growth in mice. In this study, we examined the contribution of cone mediated retinal pathways to normal refractive development and to visual form-deprivation (FD) in a mouse model lacking functional cone photoreceptors (Gnat2).

Methods: Refractive development of Gnat2and age-matched wild-type (WT) mice, were measured every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular FD in the right eye from 4 weeks of age using head-mounted diffuser goggles. Refraction, corneal curvature,and ocular biometrics were obtained using photorefraction, keratometry and spectral-domain optical coherence tomography.
Original languageEnglish
Number of pages2
Publication statusPublished - Nov 2016
Externally publishedYes
EventAcademy 2016: Current State of Health Care and Research - Orlando, United States
Duration: 9 Nov 2016 → …

Conference

ConferenceAcademy 2016
CountryUnited States
CityOrlando
Period9/11/16 → …

Keywords

  • rod photoreceptors
  • cone mediated retinal pathways
  • mice
  • refractive development
  • visual form-deprivation (FD)

Fingerprint Dive into the research topics of 'Absence of cone mediated retinal pathways increases susceptibility to form-deprivation myopia in mice'. Together they form a unique fingerprint.

  • Cite this