Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Ranjay Chakraborty, Duk Lee, Erica Landis, Michael Bergen, Curran Sidhu, Samar Hattar, P. Michael Iuvone, Richard A. Stone, Machelle Pardue

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Abstract

Purpose
ipRGCs regulate a range of non-image forming functions of light
such as modulation of circadian activity and pupillary light reflex.
Their intrinsic response to light influences intra-retinal signaling and
retinal dopaminergic cell activity. This study examined the role of
ipRGCs in refractive development of the eye under normal and formdeprived
(FD) visual conditions, using a mutant mouse in which the
ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).
Original languageEnglish
Pages7-8
Number of pages2
DOIs
Publication statusPublished - Sep 2015
Externally publishedYes
Event15th International Myopia Conference - Wenzhou, China
Duration: 23 Sep 201527 Sep 2015

Conference

Conference15th International Myopia Conference
CountryChina
CityWenzhou
Period23/09/1527/09/15

Bibliographical note

' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'

Keywords

  • photosensitive
  • retinal
  • refractive development
  • mice

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    Chakraborty, R., Lee, D., Landis, E., Bergen, M., Sidhu, C., Hattar, S., Iuvone, P. M., Stone, R. A., & Pardue, M. (2015). Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice. 7-8. Abstract from 15th International Myopia Conference, Wenzhou, China. https://doi.org/10.1186/s40662-016-0057-3