Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Ranjay Chakraborty; Duk Lee; Erica Landis; Michael Bergen; Curran Sidhu; Samar Hattar; P. Michael Iuvone; Richard A. Stone; Machelle Pardue

doi:10.1186/s40662-016-0057-3

Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Ranjay Chakraborty, Duk Lee, Erica Landis, Michael Bergen, Curran Sidhu, Samar Hattar, P. Michael Iuvone, Richard A. Stone, Machelle Pardue

Research output: Contribution to conference › Abstract › peer-review

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Abstract

Purpose
ipRGCs regulate a range of non-image forming functions of light
such as modulation of circadian activity and pupillary light reflex.
Their intrinsic response to light influences intra-retinal signaling and
retinal dopaminergic cell activity. This study examined the role of
ipRGCs in refractive development of the eye under normal and formdeprived
(FD) visual conditions, using a mutant mouse in which the
ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

Original language	English
Pages	7-8
Number of pages	2
DOIs	https://doi.org/10.1186/s40662-016-0057-3
Publication status	Published - Sept 2015
Externally published	Yes
Event	15th International Myopia Conference - Wenzhou, China Duration: 23 Sept 2015 → 27 Sept 2015

Conference

Conference	15th International Myopia Conference
Country/Territory	China
City	Wenzhou
Period	23/09/15 → 27/09/15

Bibliographical note

' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'

Keywords

photosensitive
retinal
refractive development
mice

Access to Document

10.1186/s40662-016-0057-3Licence: CC BY

Published versionFinal published version, 372 KBLicence: CC BY

Cite this

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title = "Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice",

abstract = "PurposeipRGCs regulate a range of non-image forming functions of lightsuch as modulation of circadian activity and pupillary light reflex.Their intrinsic response to light influences intra-retinal signaling andretinal dopaminergic cell activity. This study examined the role ofipRGCs in refractive development of the eye under normal and formdeprived(FD) visual conditions, using a mutant mouse in which theipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).",

keywords = "photosensitive, retinal, refractive development, mice",

author = "Ranjay Chakraborty and Duk Lee and Erica Landis and Michael Bergen and Curran Sidhu and Samar Hattar and Iuvone, {P. Michael} and Stone, {Richard A.} and Machelle Pardue",

note = "' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'; 15th International Myopia Conference ; Conference date: 23-09-2015 Through 27-09-2015",

year = "2015",

month = sep,

doi = "10.1186/s40662-016-0057-3",

language = "English",

pages = "7--8",

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TY - CONF

T1 - Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

AU - Chakraborty, Ranjay

AU - Lee, Duk

AU - Landis, Erica

AU - Bergen, Michael

AU - Sidhu, Curran

AU - Hattar, Samar

AU - Iuvone, P. Michael

AU - Stone, Richard A.

AU - Pardue, Machelle

N1 - ' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'

PY - 2015/9

Y1 - 2015/9

N2 - PurposeipRGCs regulate a range of non-image forming functions of lightsuch as modulation of circadian activity and pupillary light reflex.Their intrinsic response to light influences intra-retinal signaling andretinal dopaminergic cell activity. This study examined the role ofipRGCs in refractive development of the eye under normal and formdeprived(FD) visual conditions, using a mutant mouse in which theipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

AB - PurposeipRGCs regulate a range of non-image forming functions of lightsuch as modulation of circadian activity and pupillary light reflex.Their intrinsic response to light influences intra-retinal signaling andretinal dopaminergic cell activity. This study examined the role ofipRGCs in refractive development of the eye under normal and formdeprived(FD) visual conditions, using a mutant mouse in which theipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

KW - photosensitive

KW - retinal

KW - refractive development

KW - mice

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123376/

U2 - 10.1186/s40662-016-0057-3

DO - 10.1186/s40662-016-0057-3

M3 - Abstract

SP - 7

EP - 8

T2 - 15th International Myopia Conference

Y2 - 23 September 2015 through 27 September 2015

ER -

Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Abstract

Conference

Bibliographical note

Keywords

Access to Document

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Cite this