Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Ranjay Chakraborty; Duk Lee; Erica Landis; Michael Bergen; Curran Sidhu; Samar Hattar; P. Michael Iuvone; Richard A. Stone; Machelle Pardue

doi:10.1186/s40662-016-0057-3

Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Ranjay Chakraborty
, Duk Lee
, Erica Landis
, Michael Bergen
, Curran Sidhu
, Samar Hattar
, P. Michael Iuvone
, Richard A. Stone
, Machelle Pardue

Research output: Contribution to conference › Abstract › peer-review

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Abstract

Purpose
ipRGCs regulate a range of non-image forming functions of light
such as modulation of circadian activity and pupillary light reflex.
Their intrinsic response to light influences intra-retinal signaling and
retinal dopaminergic cell activity. This study examined the role of
ipRGCs in refractive development of the eye under normal and formdeprived
(FD) visual conditions, using a mutant mouse in which the
ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

Original language	English
Pages	7-8
Number of pages	2
DOIs	https://doi.org/10.1186/s40662-016-0057-3
Publication status	Published - Sept 2015
Externally published	Yes
Event	15th International Myopia Conference - Wenzhou, China Duration: 23 Sept 2015 → 27 Sept 2015

Conference

Conference	15th International Myopia Conference
Country/Territory	China
City	Wenzhou
Period	23/09/15 → 27/09/15

Bibliographical note

' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'

Keywords

photosensitive
retinal
refractive development
mice

Access to Document

10.1186/s40662-016-0057-3Licence: CC BY

Published versionFinal published version, 372 KBLicence: CC BY

Cite this

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title = "Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice",

abstract = "Purpose ipRGCs regulate a range of non-image forming functions of light such as modulation of circadian activity and pupillary light reflex. Their intrinsic response to light influences intra-retinal signaling and retinal dopaminergic cell activity. This study examined the role of ipRGCs in refractive development of the eye under normal and formdeprived (FD) visual conditions, using a mutant mouse in which the ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).",

keywords = "photosensitive, retinal, refractive development, mice",

author = "Ranjay Chakraborty and Duk Lee and Erica Landis and Michael Bergen and Curran Sidhu and Samar Hattar and Iuvone, \{P. Michael\} and Stone, \{Richard A.\} and Machelle Pardue",

note = "' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'; 15th International Myopia Conference ; Conference date: 23-09-2015 Through 27-09-2015",

year = "2015",

month = sep,

doi = "10.1186/s40662-016-0057-3",

language = "English",

pages = "7--8",

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TY - CONF

T1 - Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

AU - Chakraborty, Ranjay

AU - Lee, Duk

AU - Landis, Erica

AU - Bergen, Michael

AU - Sidhu, Curran

AU - Hattar, Samar

AU - Iuvone, P. Michael

AU - Stone, Richard A.

AU - Pardue, Machelle

N1 - ' This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.'

PY - 2015/9

Y1 - 2015/9

N2 - Purpose ipRGCs regulate a range of non-image forming functions of light such as modulation of circadian activity and pupillary light reflex. Their intrinsic response to light influences intra-retinal signaling and retinal dopaminergic cell activity. This study examined the role of ipRGCs in refractive development of the eye under normal and formdeprived (FD) visual conditions, using a mutant mouse in which the ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

AB - Purpose ipRGCs regulate a range of non-image forming functions of light such as modulation of circadian activity and pupillary light reflex. Their intrinsic response to light influences intra-retinal signaling and retinal dopaminergic cell activity. This study examined the role of ipRGCs in refractive development of the eye under normal and formdeprived (FD) visual conditions, using a mutant mouse in which the ipRGCs are ablated by diphtheria toxin (Opn4DTA/DTA).

KW - photosensitive

KW - retinal

KW - refractive development

KW - mice

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123376/

U2 - 10.1186/s40662-016-0057-3

DO - 10.1186/s40662-016-0057-3

M3 - Abstract

SP - 7

EP - 8

T2 - 15th International Myopia Conference

Y2 - 23 September 2015 through 27 September 2015

ER -

Absence of intrinsically photosensitive retinal ganglion cells (ipRGC) alters normal refractive development in mice

Abstract

Conference

Bibliographical note

Keywords

Access to Document

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Cite this