Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia

Charlotte EJ Downes; Barbara J McClure; John B Bruning; James Breen; Jacqueline A Rehn; David Yeung; Deborah L White

Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia

Charlotte EJ Downes, Barbara J McClure, John B Bruning, James Breen, Jacqueline A Rehn, David Yeung, Deborah L White

Research output: Contribution to conference › Poster

Abstract

We modelled and characterised acquired rux resistance in JAK2r B-ALL in vitro to study potential resistance mechanisms and investigate therapeutic strategies to overcome or avert resistance.

Original language	English
Number of pages	1
Publication status	Published - 2021
Externally published	Yes
Event	33rd Annual Lorne Cancer Conference 2021 - Lorne, Australia Duration: 11 Feb 2021 → 13 Feb 2021

Conference

Conference	33rd Annual Lorne Cancer Conference 2021
Country/Territory	Australia
City	Lorne
Period	11/02/21 → 13/02/21

Keywords

Mutations
JAK2
Lymphoblastic Leukaemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

1 Article

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia
Downes, C. E. J., McClure, B. J., Bruning, J. B., Page, E., Breen, J., Rehn, J., Yeung, D. T. & White, D. L., 10 Aug 2021, In: npj Precision Oncology. 5, 13 p., 75.
Research output: Contribution to journal › Article › peer-review

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@conference{bd42f4b4556941f99a18a1d86bb75da5,

title = "Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia ",

abstract = "We modelled and characterised acquired rux resistance in JAK2r B-ALL in vitro to study potential resistance mechanisms and investigate therapeutic strategies to overcome or avert resistance.",

keywords = "Mutations, JAK2, Lymphoblastic Leukaemia",

author = "Downes, {Charlotte EJ} and McClure, {Barbara J} and Bruning, {John B} and James Breen and Rehn, {Jacqueline A} and David Yeung and White, {Deborah L}",

year = "2021",

language = "English",

note = "33rd Annual Lorne Cancer Conference 2021 ; Conference date: 11-02-2021 Through 13-02-2021",

}

Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia . / Downes, Charlotte EJ; McClure, Barbara J; Bruning, John B et al.
2021. Poster session presented at 33rd Annual Lorne Cancer Conference 2021, Lorne, Victoria, Australia.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia

AU - Downes, Charlotte EJ

AU - McClure, Barbara J

AU - Bruning, John B

AU - Breen, James

AU - Rehn, Jacqueline A

AU - Yeung, David

AU - White, Deborah L

PY - 2021

Y1 - 2021

N2 - We modelled and characterised acquired rux resistance in JAK2r B-ALL in vitro to study potential resistance mechanisms and investigate therapeutic strategies to overcome or avert resistance.

AB - We modelled and characterised acquired rux resistance in JAK2r B-ALL in vitro to study potential resistance mechanisms and investigate therapeutic strategies to overcome or avert resistance.

KW - Mutations

KW - JAK2

KW - Lymphoblastic Leukaemia

M3 - Poster

T2 - 33rd Annual Lorne Cancer Conference 2021

Y2 - 11 February 2021 through 13 February 2021

ER -

Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of a high-risk acute lymphoblastic leukaemia

Abstract

Conference

Keywords

UN SDGs

Fingerprint

Research output

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

Cite this