Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL

Charlotte EJ Downes; Barbara J McClure; John B Bruning; James Breen; Jacqueline A Rehn; David T Yeung; Deborah L White

Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL

Charlotte EJ Downes, Barbara J McClure, John B Bruning, James Breen, Jacqueline A Rehn, David T Yeung, Deborah L White

Research output: Contribution to conference › Poster

Abstract

JAK2r (Janus kinase 2-rearrangements) occur in ~5% of paediatric B-ALL (B-cell acute lymphoblastic leukaemia) patients and are associated with poor prognosis1,3.

Original language	English
Number of pages	1
Publication status	Published - May 2021
Externally published	Yes
Event	European School of Haematology (ESH) 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia - (virtual) Duration: 7 May 2021 → 9 May 2021

Conference

Conference	European School of Haematology (ESH) 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia
Abbreviated title	ESH 2nd Translational Research Conference: ALL
Period	7/05/21 → 9/05/21

Keywords

Acquired Mutations
JAK2
Resistance

1 Article

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia
Downes, C. E. J., McClure, B. J., Bruning, J. B., Page, E., Breen, J., Rehn, J., Yeung, D. T. & White, D. L., 10 Aug 2021, In: npj Precision Oncology. 5, 13 p., 75.
Research output: Contribution to journal › Article › peer-review

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title = "Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL",

abstract = "JAK2r (Janus kinase 2-rearrangements) occur in ~5% of paediatric B-ALL (B-cell acute lymphoblastic leukaemia) patients and are associated with poor prognosis1,3.",

keywords = "Acquired Mutations, JAK2, Resistance",

author = "Downes, {Charlotte EJ} and McClure, {Barbara J} and Bruning, {John B} and James Breen and Rehn, {Jacqueline A} and Yeung, {David T} and White, {Deborah L}",

year = "2021",

month = may,

language = "English",

note = "European School of Haematology (ESH) 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia, ESH 2nd Translational Research Conference: ALL ; Conference date: 07-05-2021 Through 09-05-2021",

}

Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL. / Downes, Charlotte EJ; McClure, Barbara J; Bruning, John B et al.
2021. Poster session presented at European School of Haematology (ESH) 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL

AU - Downes, Charlotte EJ

AU - McClure, Barbara J

AU - Bruning, John B

AU - Breen, James

AU - Rehn, Jacqueline A

AU - Yeung, David T

AU - White, Deborah L

PY - 2021/5

Y1 - 2021/5

N2 - JAK2r (Janus kinase 2-rearrangements) occur in ~5% of paediatric B-ALL (B-cell acute lymphoblastic leukaemia) patients and are associated with poor prognosis1,3.

AB - JAK2r (Janus kinase 2-rearrangements) occur in ~5% of paediatric B-ALL (B-cell acute lymphoblastic leukaemia) patients and are associated with poor prognosis1,3.

KW - Acquired Mutations

KW - JAK2

KW - Resistance

M3 - Poster

T2 - European School of Haematology (ESH) 2nd Translational Research Conference: Acute Lymphoblastic Leukaemia

Y2 - 7 May 2021 through 9 May 2021

ER -

Acquired Mutations within the JAK2 Kinase Domain confer Resistance to JAK Inhibitors in in vitro Models of High-Risk ALL

Abstract

Conference

Keywords

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Research output

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

Cite this