Acromegaly as a stress response? Historical and evolutionary perspectives

Francesco M Galassi, Michael E. Habicht, Sandra Mathews, Emanuele Armocida, Martin F. Haeusler

Research output: Contribution to journalArticle


The antiquity and evolution of acromegaly are still open questions in endocrinology. This article highlights the presence of the disease in ancient civilizations and the fact that, while it is present in anatomically modern humans, no actual reports exist on its presence in great apes and extinct hominins. It then offers an evolutionary interpretation for the condition in terms of a stress response.
Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalVesalius: Acta Internationales Historiae Medicinae
Issue number1
Publication statusPublished - Jun 2021


  • Acromegaly
  • paleopathology
  • gigantism
  • Pulcinella


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