Action plan for optimizing the design of clinical trials in chronic kidney disease

Vlado Perkovic; Jonathan Craig; Worawon Chailimpamontree; Caroline Fox; Guillermo Garcia-Garcia; Mohammed Gharbi; Meg Jardine; Ikechi Okpechi; Neesh Pannu; Benedicte Stengel; Katherine Tuttle; Katrin Uhlig; Andrew Levey

doi:10.1016/j.kisu.2017.07.009

Action plan for optimizing the design of clinical trials in chronic kidney disease

Vlado Perkovic, Jonathan Craig, Worawon Chailimpamontree, Caroline Fox, Guillermo Garcia-Garcia, Mohammed Gharbi, Meg Jardine, Ikechi Okpechi, Neesh Pannu, Benedicte Stengel, Katherine Tuttle, Katrin Uhlig, Andrew Levey

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.

Original language	English
Pages (from-to)	138-144
Number of pages	7
Journal	Kidney International Supplements
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.kisu.2017.07.009
Publication status	Published - Oct 2017
Event	2016 International Society of Nephrology Conference - Duration: 1 Jul 2016 → …

Keywords

chronic kidney disease
clinical trial
clinical trial design
clinical trial endpoints

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10.1016/j.kisu.2017.07.009

Cite this

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abstract = "High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.",

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AU - Garcia-Garcia, Guillermo

AU - Gharbi, Mohammed

AU - Jardine, Meg

AU - Okpechi, Ikechi

AU - Pannu, Neesh

AU - Stengel, Benedicte

AU - Tuttle, Katherine

AU - Uhlig, Katrin

AU - Levey, Andrew

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Action plan for optimizing the design of clinical trials in chronic kidney disease

Abstract

Keywords

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