Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System

Bradley B. Barth, Nick J. Spencer, Warren M. Grill

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

The characteristic motor patterns of the colon are coordinated by the enteric nervous system (ENS) and involve enterochromaffin (EC) cells, enteric glia, smooth muscle fibers, and interstitial cells. While the fundamental control mechanisms of colonic motor patterns are understood, greater complexity in the circuitry underlying motor patterns has been revealed by recent advances in the field. We review these recent advances and new findings from our laboratories that provide insights into how the ENS coordinates motor patterns in the isolated mouse colon. We contextualize these observations by describing the neuromuscular system underling the colonic motor complex (CMC) as a robust, distributed control system. Framing the colonic motor complex as a control system reveals a new perspective on the coordinated motor patterns in the colon. We test the control system by applying electrical stimulation in the isolated mouse colon to disrupt the coordination and propagation of the colonic motor complex.

Original languageEnglish
Title of host publicationThe Enteric Nervous System II
EditorsNick J. Spencer, Marcello Costa, Stuart M. Brierley
Place of PublicationCham, Switzerland
PublisherSpringer
Chapter11
Pages113-123
Number of pages11
ISBN (Electronic)978-3-031-05843-1
ISBN (Print)978-3-031-05842-4
DOIs
Publication statusPublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1383
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Colonic migrating motor complex
  • Control system
  • Enteric circuitry
  • Enteric nervous system

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