@inbook{cdc3f7af982f41cca932750d8adc712a,
title = "Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System",
abstract = "The characteristic motor patterns of the colon are coordinated by the enteric nervous system (ENS) and involve enterochromaffin (EC) cells, enteric glia, smooth muscle fibers, and interstitial cells. While the fundamental control mechanisms of colonic motor patterns are understood, greater complexity in the circuitry underlying motor patterns has been revealed by recent advances in the field. We review these recent advances and new findings from our laboratories that provide insights into how the ENS coordinates motor patterns in the isolated mouse colon. We contextualize these observations by describing the neuromuscular system underling the colonic motor complex (CMC) as a robust, distributed control system. Framing the colonic motor complex as a control system reveals a new perspective on the coordinated motor patterns in the colon. We test the control system by applying electrical stimulation in the isolated mouse colon to disrupt the coordination and propagation of the colonic motor complex.",
keywords = "Colonic migrating motor complex, Control system, Enteric circuitry, Enteric nervous system",
author = "Barth, {Bradley B.} and Spencer, {Nick J.} and Grill, {Warren M.}",
year = "2022",
doi = "10.1007/978-3-031-05843-1_11",
language = "English",
isbn = "978-3-031-05842-4 ",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer ",
pages = "113--123",
editor = "Spencer, {Nick J.} and Marcello Costa and Brierley, {Stuart M.}",
booktitle = "The Enteric Nervous System II",
}