Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat

J. O. Willoughby, M. F. Menadue, H. Liebelt

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    In conscious rats, serotonin microinjected into the basal hypothalamus caused secretion of GH maximal within 10-25 min. The effects of serotonin on GH were blocked by the non-selective serotonin receptor blocker, metergoline 2.5 mg/kg, but not by the serotonin type 2 receptor blocker, ketanserine 0.2 mg/kg. Injections of serotonin in the preoptic/anterior hypothalamic area were without effect. It is concluded that activation of serotonin receptors, probably type I, on or near GH releasing factor neurons in the arcuate nucleus causes secretion of GH and that serotonin has no direct effect on or near somatostatin neurons in the preoptic anterior hypothalamic area.

    Original languageEnglish
    Pages (from-to)319-322
    Number of pages4
    JournalBrain Research
    Volume404
    Issue number1-2
    DOIs
    Publication statusPublished - 24 Feb 1987

    Keywords

    • Growth hormone
    • Medial basal hypothalamus
    • Preoptic/anterior hypothalamic area
    • Serotonin

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