Acute respiratory distress syndrome

Andrew Bersten; Shailesh Bihari

doi:10.1016/B978-0-443-11611-7.00037-2

Acute respiratory distress syndrome

College of Medicine and Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Acute respiratory distress syndrome (ARDS) is an acute diffuse, inflammatory lung injury leading to increased pulmonary permeability, increased lung weight, loss of aerated lung tissue, hypoxaemia and bilateral radiographic opacities, associated with increased physiological dead space and decreased lung compliance which is not fully explained by cardiac failure or fluid overload. Patients with ARDS have a high rate of morbidity and mortality. Lung protective invasive mechanical ventilation with adequate positive end-expiratory pressure remains the cornerstone of management, although new therapies are being developed as underlying mechanisms and pathophysiology are better understood.

Original language	English
Title of host publication	Oh's Intensive Care Manual
Editors	Jonathan M. Handy, Bala Venkatesh, Jeremy Cohen, Daniel Martin
Publisher	Elsevier
Chapter	37
Pages	442-454
Number of pages	13
Edition	9th
ISBN (Electronic)	9780443116117
ISBN (Print)	9780443116858
DOIs	https://doi.org/10.1016/B978-0-443-11611-7.00037-2
Publication status	Published - 2026

Keywords

acute respiratory distress syndrome
fluid balance
mechanical power, ventilation-induced lung injury
mechanical ventilation
positive end-expiratory pressure

Access to Document

10.1016/B978-0-443-11611-7.00037-2Licence: In Copyright

Cite this

@inbook{3a41cf94a47f4d90b7fe6b7dbaed99eb,

title = "Acute respiratory distress syndrome",

abstract = "Acute respiratory distress syndrome (ARDS) is an acute diffuse, inflammatory lung injury leading to increased pulmonary permeability, increased lung weight, loss of aerated lung tissue, hypoxaemia and bilateral radiographic opacities, associated with increased physiological dead space and decreased lung compliance which is not fully explained by cardiac failure or fluid overload. Patients with ARDS have a high rate of morbidity and mortality. Lung protective invasive mechanical ventilation with adequate positive end-expiratory pressure remains the cornerstone of management, although new therapies are being developed as underlying mechanisms and pathophysiology are better understood.",

keywords = "acute respiratory distress syndrome, fluid balance, mechanical power, ventilation-induced lung injury, mechanical ventilation, positive end-expiratory pressure",

author = "Andrew Bersten and Shailesh Bihari",

year = "2026",

doi = "10.1016/B978-0-443-11611-7.00037-2",

language = "English",

isbn = "9780443116858",

pages = "442--454",

editor = "Handy, \{Jonathan M.\} and Bala Venkatesh and Jeremy Cohen and Daniel Martin",

booktitle = "Oh's Intensive Care Manual",

publisher = "Elsevier",

edition = "9th",

}

TY - CHAP

T1 - Acute respiratory distress syndrome

AU - Bersten, Andrew

AU - Bihari, Shailesh

PY - 2026

Y1 - 2026

N2 - Acute respiratory distress syndrome (ARDS) is an acute diffuse, inflammatory lung injury leading to increased pulmonary permeability, increased lung weight, loss of aerated lung tissue, hypoxaemia and bilateral radiographic opacities, associated with increased physiological dead space and decreased lung compliance which is not fully explained by cardiac failure or fluid overload. Patients with ARDS have a high rate of morbidity and mortality. Lung protective invasive mechanical ventilation with adequate positive end-expiratory pressure remains the cornerstone of management, although new therapies are being developed as underlying mechanisms and pathophysiology are better understood.

AB - Acute respiratory distress syndrome (ARDS) is an acute diffuse, inflammatory lung injury leading to increased pulmonary permeability, increased lung weight, loss of aerated lung tissue, hypoxaemia and bilateral radiographic opacities, associated with increased physiological dead space and decreased lung compliance which is not fully explained by cardiac failure or fluid overload. Patients with ARDS have a high rate of morbidity and mortality. Lung protective invasive mechanical ventilation with adequate positive end-expiratory pressure remains the cornerstone of management, although new therapies are being developed as underlying mechanisms and pathophysiology are better understood.

KW - acute respiratory distress syndrome

KW - fluid balance

KW - mechanical power, ventilation-induced lung injury

KW - mechanical ventilation

KW - positive end-expiratory pressure

UR - https://www.scopus.com/pages/publications/105027111430

U2 - 10.1016/B978-0-443-11611-7.00037-2

DO - 10.1016/B978-0-443-11611-7.00037-2

M3 - Chapter

AN - SCOPUS:105027111430

SN - 9780443116858

SP - 442

EP - 454

BT - Oh's Intensive Care Manual

A2 - Handy, Jonathan M.

A2 - Venkatesh, Bala

A2 - Cohen, Jeremy

A2 - Martin, Daniel

PB - Elsevier

ER -

Acute respiratory distress syndrome

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this