Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

R.H.X Wong, Peter Howe, Jonathon Buckley, Alison Coates, Iris Kunz, Narelle Berry

    Research output: Contribution to journalArticlepeer-review

    211 Citations (Scopus)

    Abstract

    Background and Aims: Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD. We investigated whether consuming resveratrol, a polyphenol found in red wine, can enhance FMD acutely and whether there is a dose-response relationship for this effect. Methods and Results: 19 overweight/obese (BMI 25-35 kg m-2) men or post-menopausal women with untreated borderline hypertension (systolic BP: 130-160 mmHg or diastolic BP: 85-100 mmHg) consumed three doses of resveratrol (resVida™ 30, 90 and 270 mg) and a placebo at weekly intervals in a double-blind, randomized crossover comparison. One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log10 dose of resveratrol. 14 men and 5 women (age 55 ± 2 years, BMI 28.7 ± 0.5 kg m-2, BP 141 ± 2/89 ± 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270 mg resveratrol. FMD was also linearly related to log10 plasma resveratrol concentration (P < 0.01). Conclusion: Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.

    Original languageEnglish
    Pages (from-to)851-856
    Number of pages6
    JournalNutrition Metabolism and Cardiovascular Diseases
    Volume21
    Issue number11
    DOIs
    Publication statusPublished - Nov 2011

    Keywords

    • Blood pressure
    • Cardiovascular risk factors
    • Endothelial function
    • Flow-mediated dilatation
    • Resveratrol

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