Acyclovir and Debridement in the Treatment of Ulcerative Herpetic Keratitis

Kirk R. Wilhelmus, Douglas J. Coster, Barrie R. Jones

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


We treated 25 patients with dendritic keratitis with debridement and 3% acyclovir ointment and another 25 with acyclovir alone. The patients were randomly assigned to the two treatment groups. There were only minimal adverse effects in both groups. The combination of debridement and acyclovir produced a significantly more rapid healing rate than did acyclovir alone. Factors associated with prolonged healing time were duration of symptoms (longer than one week), length of the epithelial defect (> 4 mm), proximity of the defect to the corneoscleral limbus (< 2 mm), and the presence of stromal inflammation.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalAmerican Journal of Ophthalmology
Issue number3
Publication statusPublished - Mar 1981
Externally publishedYes


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