@article{f18ee55b3c50450db408f76f22a9eaed,
title = "Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation",
abstract = "BACKGROUND: A substantial proportion of patients receiving fibrinolytic therapy for myocardial infarction with ST-segment elevation have inadequate reperfusion or reocclusion of the infarct-related artery, leading to an increased risk of complications and death. METHODS: We enrolled 3491 patients, 18 to 75 years of age, who presented within 12 hours after the onset of an ST-elevation myocardial infarction and randomly assigned them to receive clopidogrel (300-mg loading dose, followed by 75 mg once daily) or placebo. Patients received a fibrinolytic agent, aspirin, and when appropriate, heparin (dispensed according to body weight) and were scheduled to undergo angiography 48 to 192 hours after the start of study medication. The primary efficacy end point was a composite of an occluded infarct-related artery (defined by a Thrombolysis in Myocardial Infarction flow grade of 0 or 1) on angiography or death or recurrent myocardial infarction before angiography. RESULTS: The rates of the primary efficacy end point were 21.7 percent in the placebo group and 15.0 percent in the clopidogrel group, representing an absolute reduction of 6.7 percentage points in the rate and a 36 percent reduction in the odds of the end point with clopidogrel therapy (95 percent confidence interval, 24 to 47 percent; P",
author = "Sabatine, {Marc S} and Cannon, {Christopher P} and Gibson, {C Michael} and J Lopez-Sendon and G Montalescot and Pierre Theroux and Claeys, {Marc J} and F Cools and Hill, {Karen A} and Skene, {Allan M} and McCabe, {Carolyn H} and Eugene Braunwald and {CLARITY–TIMI 28 Investigators} and A McCagg and B Job and C Gaudin and {Thizon-de Gaulle}, I and M Blumenthal and R Saini and I Delaet and L. Townes and D. Anhalt and {van Holder}, K and S Job and C Gaudin and I Delaet and L. Townes and D Ardissino and P Aylward and M Bertrand and C Bode and A Budaj and M Dellborg and R Ferreira and A Gershlick and K Huber and M Keltai and N Kleiman and B Lewis and J Marx and J Nicolau and Z Ongen and E Paolasso and {Leiva Pons}, J and M Ruda and {Van de Werf}, F and F Verheugt and R Wilcox and U Zeymer and J Froehlich and Pieters A and A Charlesworth and M Goulder and S Stead and S Wiviott and J Aroesty and C Berger and L Garcia and D Greer and D Leeman and H Lyle and G Philippides and L Schwamm and S Marble and J Buros and L Ciaglo and A Kirtane and A Shui and A Wilson and B Scirica and D Morrow and R Giugliano and S Wiviott and P Ridker and N Rifai and R Kucherlapati and D Kwiatkowski and P Stone and G Maccallum and M Lucier and A Garriga and J Anderson and K Fox and S Kelsey and A Batalla and {Lopez de Sa y Areses}, E and M Fiol and A Bethencourt and I Lozano and F Figueras and {Guiterrez Cort{\'e}s}, J and {Garcia Jimenez}, A and {Rivera Fernandez}, A and {Ferreira Montero}, I and J Casasnovas and {Ortigosa Aso}, F and {Carbonell de Blas}, R and J Audicana and {Echanove Errazti}, I and {Sala Montero}, J and I Rohlfs and C Pi{\~n}ero and {Martinez Rodriguez}, M and {Velasco Alvarez}, L and {Castro Belras}, A and S Barros and {Diaz Fern{\'a}ndez}, J and A Tobaruela and A Bonneau and L Soulat and Y Lambert and J Caussanel and B Livareck and C Ramaut and J Ricome and F Lapostolle and A Beruben and F Thieleux and J Martelli and Etori and M Martelet and J Mouallem and F Ahmed and D Galley and S Alhabaj and Strateman and D Doucos and E Bearez and S Spetebroodt and C Gully and J Dujardin and B Averland and B Emmonot and D Pollet and P Vallet and R Mossaz and A Marquand and A Kermarrec and {Le Lay}, C and R Douillet and L Olliver and O Matas and S Kassam and F Halperin and P Parsons and B Bovak and B Hart and B Sussex and S Newman and G Gosselin and M David and K Sidhar and D Wiseman and C Lefkowitz and M Thornley and R Bhargava and A McCullum and D Grandmond and D Carignan and S Kouz and M Roy and P Polasek and V Stedham and K Lai and B Paquette and D Raco and M Sayles and B Tremblay and C Darveau and M Senaratne and M Holland and I Bata and M Hulan and C Constance and S Pouliot and D Gossard and L Day and A Glanz and C Vilag and W Hui and L Kvill and D Dion and A Morisette and F Sandrin and S Mitges and S Vanhagendoren and {De Meester}, A and O Marcovitch and E Allaf and F Gits and J Verrostte and J Thoeng and M Quinonez and H Appeltants and G D'Hooghe and M Eyken and I Swennen and G Hollanders and E Micha{\"e}l and P Decroly and E Rombaut and D Carlaire and D Vermander and Marenne, {St F} and C Gavray and P Michel and A Poth and J Paquay and S Lutasu and D Dirk and J Vermeulen and E Govaerts and S Boldueva and A Sherenkov and V Kostenko and S Tereschenko and G Zalevsky and M Boyarkin and B Tankhilevitch and M Glezer and N Gratsiansky and E Shlyakhto and B Sidorenko and V Zadiontchenko and D Chew",
year = "2005",
month = mar,
day = "24",
doi = "10.1056/NEJMoa050522",
language = "English",
volume = "352",
pages = "1179--1189",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachusetts Medical Society",
number = "12",
}