Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment

Kelton Tremellen, P Russell

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Abstract

    Four women, who previously had undergone multiple unsuccessful in vitro fertilisation (IVF) cycles because of failure of implantation of good quality embryos, were identified as having coexisting uterine adenomyosis. Endometrial biopsies showed that adenomyosis was associated with a prominent aggregation of macrophages within the superficial endometrial glands, potentially interfering with embryo implantation. The inactivation of adenomyosis by an ultra-long pituitary downregulation regime promptly resulted in successful pregnancy for all women in this case series.

    Original languageEnglish
    Pages (from-to)280-283
    Number of pages4
    JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
    Volume51
    Issue number3
    DOIs
    Publication statusPublished - Jun 2011

    Keywords

    • adenomyosis
    • GnRH agonist
    • implantation
    • in vitro fertilisation
    • macrophage

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