Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart Eijkelkamp, Uwe Stroeher, Karl Hassan, Michael Papadimitrious, Ian Paulsen, Melissa Brown

    Research output: Contribution to journalArticle

    90 Citations (Scopus)

    Abstract

    Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

    Original languageEnglish
    Pages (from-to)44-51
    Number of pages8
    JournalFEMS Microbiology Letters
    Volume323
    Issue number1
    DOIs
    Publication statusPublished - Oct 2011

    Keywords

    • Australian clinical strains
    • Biofilm formation
    • Eukaryotic cell adherence
    • Swarming
    • Twitching
    • Type IV pili

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