Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart Eijkelkamp; Uwe Stroeher; Karl Hassan; Michael Papadimitrious; Ian Paulsen; Melissa Brown

doi:10.1111/j.1574-6968.2011.02362.x

Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart Eijkelkamp, Uwe Stroeher, Karl Hassan, Michael Papadimitrious, Ian Paulsen, Melissa Brown

Research output: Contribution to journal › Article › peer-review

143 Citations (Scopus)

Abstract

Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	FEMS Microbiology Letters
Volume	323
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2011.02362.x
Publication status	Published - Oct 2011

Keywords

Australian clinical strains
Biofilm formation
Eukaryotic cell adherence
Swarming
Twitching
Type IV pili

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10.1111/j.1574-6968.2011.02362.x

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AU - Paulsen, Ian

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Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

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Keywords

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