Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

Kuo Chen, Jin Zhang, Narasimha M. Beeraka, Chengyun Tang, Yulia V. Babayeva, Mikhail Y. Sinelnikov, Xinliang Zhang, Jiacheng Zhang, Junqi Liu, Igor V. Reshetov, Olga A. Sukocheva, Pengwei Lu, Ruitai Fan

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)
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Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC) growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory cytokines are involved in the development of obesity-driven BC through the activation of multiple oncogenic and pro-inflammatory pathways. The aim of this study was to assess the reported mechanisms of obesity-induced breast carcinogenesis and effectiveness of conventional and complementary BC therapies. We screened published original articles, reviews, and meta-analyses that addressed the involvement of obesity-related signaling mechanisms in BC development, BC treatment/prevention approaches, and posttreatment complications. PubMed, Medline, eMedicine, National Library of Medicine (NLM), and ReleMed databases were used to retrieve relevant studies using a set of keywords, including “obesity,” “oncogenic signaling pathways,” “inflammation,” “surgery,” “radiotherapy,” “conventional therapies,” and “diet.” Multiple studies indicated that effective BC treatment requires the involvement of diet- and exercise-based approaches in obese postmenopausal women. Furthermore, active lifestyle and diet-related interventions improved the patients’ overall quality of life and minimized adverse side effects after traditional BC treatment, including postsurgical lymphedema, post-chemo nausea, vomiting, and fatigue. Further investigation of beneficial effects of diet and physical activity may help improve obesity-linked cancer therapies.

Original languageEnglish
Article number820968
Number of pages22
JournalFrontiers in Oncology
Publication statusPublished - 22 Jun 2022


  • breast cancer
  • estrogen
  • inflammation
  • neoadjuvant therapy
  • obesity
  • oncogenic signaling
  • preventive measures


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