Age-related variations in human lymphocyte DNA

D. R. Turner; A. A. Morley; R. S. Seshadri; Judith R. Sorrell

doi:10.1016/0047-6374(81)90068-3

Age-related variations in human lymphocyte DNA

D. R. Turner, A. A. Morley, R. S. Seshadri, Judith R. Sorrell

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17 Citations (Scopus)

Abstract

The molecular weigth of DNA from human peripheral lymphocytes has been measured on alkaline sucrose density gradients. The number average molecular weight (M_N) of DNA is found to decrease as the age of the donor increases. This result is discussed with reference to lesions in DNA, both repairable and non-repairable, which may accumulate with age.

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Mechanisms of Ageing and Development
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0047-6374(81)90068-3
Publication status	Published - Nov 1981

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title = "Age-related variations in human lymphocyte DNA",

abstract = "The molecular weigth of DNA from human peripheral lymphocytes has been measured on alkaline sucrose density gradients. The number average molecular weight (MN) of DNA is found to decrease as the age of the donor increases. This result is discussed with reference to lesions in DNA, both repairable and non-repairable, which may accumulate with age.",

author = "Turner, {D. R.} and Morley, {A. A.} and Seshadri, {R. S.} and Sorrell, {Judith R.}",

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AU - Turner, D. R.

AU - Morley, A. A.

AU - Seshadri, R. S.

AU - Sorrell, Judith R.

PY - 1981/11

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N2 - The molecular weigth of DNA from human peripheral lymphocytes has been measured on alkaline sucrose density gradients. The number average molecular weight (MN) of DNA is found to decrease as the age of the donor increases. This result is discussed with reference to lesions in DNA, both repairable and non-repairable, which may accumulate with age.

AB - The molecular weigth of DNA from human peripheral lymphocytes has been measured on alkaline sucrose density gradients. The number average molecular weight (MN) of DNA is found to decrease as the age of the donor increases. This result is discussed with reference to lesions in DNA, both repairable and non-repairable, which may accumulate with age.

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U2 - 10.1016/0047-6374(81)90068-3

DO - 10.1016/0047-6374(81)90068-3

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AN - SCOPUS:0019800947

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VL - 17

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JO - Mechanisms of Ageing and Development

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Age-related variations in human lymphocyte DNA

Abstract

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