Ageing in vivo does not alter the kinetics of DNA strand break repair

D. R. Turner, Virginia C. Griffith, A. A. Morley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The alkaline elution technique has been used to measure the apparent rate constant for repair of DNA strand breaks induced by X-radiation in human transformed lymphocyte DNA. Repair follows first-order kinetics and is essentially complete within 60 min. Although biological variation is observed there is no significant change in rate of repair with age of lymphocyte donor. In light of this it is unlikely that age-associated changes in DNA which have been widely observed arise from a changed persistence of strand breaks.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalMechanisms of Ageing and Development
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 1982
Externally publishedYes

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