Ageing in vivo does not alter the kinetics of DNA strand break repair

D. R. Turner; Virginia C. Griffith; A. A. Morley

doi:10.1016/0047-6374(82)90016-1

Ageing in vivo does not alter the kinetics of DNA strand break repair

D. R. Turner, Virginia C. Griffith, A. A. Morley

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Abstract

The alkaline elution technique has been used to measure the apparent rate constant for repair of DNA strand breaks induced by X-radiation in human transformed lymphocyte DNA. Repair follows first-order kinetics and is essentially complete within 60 min. Although biological variation is observed there is no significant change in rate of repair with age of lymphocyte donor. In light of this it is unlikely that age-associated changes in DNA which have been widely observed arise from a changed persistence of strand breaks.

Original language	English
Pages (from-to)	325-331
Number of pages	7
Journal	Mechanisms of Ageing and Development
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0047-6374(82)90016-1
Publication status	Published - Aug 1982
Externally published	Yes

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title = "Ageing in vivo does not alter the kinetics of DNA strand break repair",

abstract = "The alkaline elution technique has been used to measure the apparent rate constant for repair of DNA strand breaks induced by X-radiation in human transformed lymphocyte DNA. Repair follows first-order kinetics and is essentially complete within 60 min. Although biological variation is observed there is no significant change in rate of repair with age of lymphocyte donor. In light of this it is unlikely that age-associated changes in DNA which have been widely observed arise from a changed persistence of strand breaks.",

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AU - Turner, D. R.

AU - Griffith, Virginia C.

AU - Morley, A. A.

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N2 - The alkaline elution technique has been used to measure the apparent rate constant for repair of DNA strand breaks induced by X-radiation in human transformed lymphocyte DNA. Repair follows first-order kinetics and is essentially complete within 60 min. Although biological variation is observed there is no significant change in rate of repair with age of lymphocyte donor. In light of this it is unlikely that age-associated changes in DNA which have been widely observed arise from a changed persistence of strand breaks.

AB - The alkaline elution technique has been used to measure the apparent rate constant for repair of DNA strand breaks induced by X-radiation in human transformed lymphocyte DNA. Repair follows first-order kinetics and is essentially complete within 60 min. Although biological variation is observed there is no significant change in rate of repair with age of lymphocyte donor. In light of this it is unlikely that age-associated changes in DNA which have been widely observed arise from a changed persistence of strand breaks.

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Ageing in vivo does not alter the kinetics of DNA strand break repair

Abstract

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