Aging in the nervous system of Caenorhabditis elegans

Yee Lian Chew, Xiaochen Fan, Jürgen Götz, Hannah R. Nicholas

Research output: Contribution to journalShort surveypeer-review

7 Citations (Scopus)

Abstract

It has recently been described that aging in C. elegans is accompanied by the progressive development of morphological changes in the nervous system. These include novel outgrowths from the cell body or axonal process, as well as blebbing and beading along the length of the axon. The formation of these structures is regulated by numerous molecular players including members of the wellconserved insulin/insulin growth factor-like (IGF)-1 signaling and mitogen-activated protein (MAP) kinase pathways. This review summarizes the recent literature on neuronal aging in C. elegans, including our own findings, which indicate a role for protein with tau-like repeats (PTL-1), the homolog of mammalian tau and MAP2/4, in maintaining neuronal integrity during aging.

Original languageEnglish
Article numbere25288
Number of pages6
JournalCommunicative and Integrative Biology
Volume6
Issue number5
DOIs
Publication statusPublished - 18 Jun 2013
Externally publishedYes

Keywords

  • Aging
  • Caenorhabditis elegans
  • Lifespan
  • Neuronal aging
  • Protein with tau-like repeats

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