Aldoximes enable proton-relayed NMR hyperpolarisation

Naomi E. Leydman; Philip L. Norcott

doi:10.1039/d4cc03231d

Aldoximes enable proton-relayed NMR hyperpolarisation

Naomi E. Leydman, Philip L. Norcott

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Abstract

NMR signals can be greatly enhanced, or hyperpolarised, by interactions with para-hydrogen. We demonstrate here that oximes can be reversibly hyperpolarised by coordination to an iridium complex, that oxime E/Z geometry is significant for activity, and that hyperpolarised oximes can subsequently transfer these enhanced signals through proton exchange.

Original language	English
Pages (from-to)	9761-9764
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	72
DOIs	https://doi.org/10.1039/d4cc03231d
Publication status	Published - 15 Sept 2024
Externally published	Yes

Keywords

Aldoximes
hyperpolarisation
proton exchange

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10.1039/d4cc03231dLicence: CC BY-NC

Final published versionFinal published version, 965 KBLicence: CC BY-NC

Cite this

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title = "Aldoximes enable proton-relayed NMR hyperpolarisation",

abstract = "NMR signals can be greatly enhanced, or hyperpolarised, by interactions with para-hydrogen. We demonstrate here that oximes can be reversibly hyperpolarised by coordination to an iridium complex, that oxime E/Z geometry is significant for activity, and that hyperpolarised oximes can subsequently transfer these enhanced signals through proton exchange.",

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AU - Leydman, Naomi E.

AU - Norcott, Philip L.

PY - 2024/9/15

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N2 - NMR signals can be greatly enhanced, or hyperpolarised, by interactions with para-hydrogen. We demonstrate here that oximes can be reversibly hyperpolarised by coordination to an iridium complex, that oxime E/Z geometry is significant for activity, and that hyperpolarised oximes can subsequently transfer these enhanced signals through proton exchange.

AB - NMR signals can be greatly enhanced, or hyperpolarised, by interactions with para-hydrogen. We demonstrate here that oximes can be reversibly hyperpolarised by coordination to an iridium complex, that oxime E/Z geometry is significant for activity, and that hyperpolarised oximes can subsequently transfer these enhanced signals through proton exchange.

KW - Aldoximes

KW - hyperpolarisation

KW - proton exchange

UR - http://www.scopus.com/inward/record.url?scp=85201855784&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/ARC/DE210100065

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DO - 10.1039/d4cc03231d

M3 - Article

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AN - SCOPUS:85201855784

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VL - 60

SP - 9761

EP - 9764

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Aldoximes enable proton-relayed NMR hyperpolarisation

Abstract

Keywords

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