Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model

Geetha Mohan; Egon Perilli; Julia Kuliwaba; Julia Humphries; Ian Parkinson; Nicola Fazzalari

Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model

Geetha Mohan, Egon Perilli, Julia Kuliwaba, Julia Humphries, Ian Parkinson, Nicola Fazzalari

Research output: Contribution to conference › Abstract › peer-review

Abstract

In this study, the efficacy of alendronate (ALN) treatment on
tibial subchondral bone was evaluated using in vivo microCT in
a rat model of low-dose monosodium iodoacetate-induced
(MIA) osteoarthritis (OA), at an early stage of the disease. Rats
(n=24) received a single intra-articular injection of 0.2 mg
MIA in the right knee to induce OA, and sterile saline in the
left knee.

Original language	English
Pages	S579
Number of pages	1
Publication status	Published - 2011
Externally published	Yes
Event	International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS - Gold Coast, Australia Duration: 4 Sept 2011 → 8 Sept 2011

Conference

Conference	International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS
Country/Territory	Australia
City	Gold Coast
Period	4/09/11 → 8/09/11

Keywords

micro-CT
animal model

Cite this

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title = "Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model",

abstract = "In this study, the efficacy of alendronate (ALN) treatment ontibial subchondral bone was evaluated using in vivo microCT ina rat model of low-dose monosodium iodoacetate-induced(MIA) osteoarthritis (OA), at an early stage of the disease. Rats(n=24) received a single intra-articular injection of 0.2 mgMIA in the right knee to induce OA, and sterile saline in theleft knee.",

keywords = "micro-CT, animal model",

author = "Geetha Mohan and Egon Perilli and Julia Kuliwaba and Julia Humphries and Ian Parkinson and Nicola Fazzalari",

year = "2011",

language = "English",

pages = "S579",

note = "International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS ; Conference date: 04-09-2011 Through 08-09-2011",

}

Mohan, G, Perilli, E, Kuliwaba, J, Humphries, J, Parkinson, I & Fazzalari, N 2011, 'Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model', International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS, Gold Coast, Australia, 4/09/11 - 8/09/11 pp. S579.

Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model. / Mohan, Geetha; Perilli, Egon; Kuliwaba, Julia et al.
2011. S579 Abstract from International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS, Gold Coast, Australia.

Research output: Contribution to conference › Abstract › peer-review

TY - CONF

T1 - Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis

T2 - International Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS

AU - Mohan, Geetha

AU - Perilli, Egon

AU - Kuliwaba, Julia

AU - Humphries, Julia

AU - Parkinson, Ian

AU - Fazzalari, Nicola

PY - 2011

Y1 - 2011

N2 - In this study, the efficacy of alendronate (ALN) treatment ontibial subchondral bone was evaluated using in vivo microCT ina rat model of low-dose monosodium iodoacetate-induced(MIA) osteoarthritis (OA), at an early stage of the disease. Rats(n=24) received a single intra-articular injection of 0.2 mgMIA in the right knee to induce OA, and sterile saline in theleft knee.

AB - In this study, the efficacy of alendronate (ALN) treatment ontibial subchondral bone was evaluated using in vivo microCT ina rat model of low-dose monosodium iodoacetate-induced(MIA) osteoarthritis (OA), at an early stage of the disease. Rats(n=24) received a single intra-articular injection of 0.2 mgMIA in the right knee to induce OA, and sterile saline in theleft knee.

KW - micro-CT

KW - animal model

M3 - Abstract

SP - S579

Y2 - 4 September 2011 through 8 September 2011

ER -

Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model

Abstract

Conference

Keywords

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