Alendronate treatment reduces tibial subchondral bone damage in early-stage osteoarthritis: an in vivo micro-CT study in a rodent model

Geetha Mohan, Egon Perilli, Julia Kuliwaba, Julia Humphries, Ian Parkinson, Nicola Fazzalari

Research output: Contribution to conferenceAbstractpeer-review

Abstract

In this study, the efficacy of alendronate (ALN) treatment on
tibial subchondral bone was evaluated using in vivo microCT in
a rat model of low-dose monosodium iodoacetate-induced
(MIA) osteoarthritis (OA), at an early stage of the disease. Rats
(n=24) received a single intra-articular injection of 0.2 mg
MIA in the right knee to induce OA, and sterile saline in the
left knee.
Original languageEnglish
PagesS579
Number of pages1
Publication statusPublished - 2011
Externally publishedYes
EventInternational Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS - Gold Coast, Australia
Duration: 4 Sep 20118 Sep 2011

Conference

ConferenceInternational Osteoporosis Foundation 2nd Asia-Pacific Osteoporosis and Bone Meeting, and ANZBMS
CountryAustralia
CityGold Coast
Period4/09/118/09/11

Keywords

  • micro-CT
  • animal model

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