Al3+ induced hydrolysis of anthraquinone-based Schiff base fluorescent probe for determination PPi ions and bioimaging

Chen Zhao, Muhammad Asif, Wenjing Lu, Shaomin Shuang, Youhong Tang, Chuan Dong

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Herein, a novel anthraquinone derivative appended fluorescent probe (HAD), has been developed as a reversible probe for detection of aluminium ions (Al3+) and pyrophosphate (PPi) in buffer medium. The probe displays fluorescence “turn-on” response towards Al3+ with high specificity. The activation of the chelation-enhanced fluorescence (CHEF) effect occurs as a consequence of the formation of a complex via coordination with Al3+, which was due to the imine bond is dynamic and reversible and further causing subsequent cleavage of the -C=N bond in the presence of Al3+. This complex significantly amplifies the fluorescence response. Additionally, according to the Job's plot and high-resolution mass spectrometry (HRMS) measurements, the binding stoichiometry of HAD and Al3+ ions is 1:2. Moreover, Density functional theory (DFT) investigations further elucidate the binding mechanism. The original spectrum is restored after the addition of PPi, which is due to the formation of more stable Al3+-PPi complex. The specific determination of Al3+ and PPi with the detecting limit of 47.6 nM and 73.7 nM (S/N = 3), respectively. Due to its exceptional biocompatibility, the probe has facilitated the development of Al3+ and PPi imaging in vitro and in vivo, thereby showcasing its remarkable capabilities in the realm of environmental and biological analysis.

Original languageEnglish
Article number124507
Number of pages11
JournalJOURNAL OF MOLECULAR LIQUIDS
Volume400
DOIs
Publication statusPublished - 15 Apr 2024

Keywords

  • Al detection
  • Bioimaging
  • Cleaving
  • Fluorescent probe
  • Hydrolysis

Fingerprint

Dive into the research topics of 'Al3+ induced hydrolysis of anthraquinone-based Schiff base fluorescent probe for determination PPi ions and bioimaging'. Together they form a unique fingerprint.

Cite this