ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS

P. R.C. Howe, M. J. West, J. P. Chalmers

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.

    Original languageEnglish
    Pages (from-to)83-86
    Number of pages4
    JournalClinical and Experimental Pharmacology and Physiology
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - Feb 1981

    Keywords

    • heart
    • hypertension
    • noradrenaline

    Fingerprint Dive into the research topics of 'ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS'. Together they form a unique fingerprint.

  • Cite this