ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS

P. R.C. Howe; M. J. West; J. P. Chalmers

doi:10.1111/j.1440-1681.1981.tb00137.x

ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS

P. R.C. Howe, M. J. West, J. P. Chalmers

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1681.1981.tb00137.x
Publication status	Published - Feb 1981

Keywords

heart
hypertension
noradrenaline

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abstract = "1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.",

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N2 - 1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.

AB - 1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.

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ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS

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