Altered nocturnal cardiovascular control in children with sleep-disordered breathing

Fatima El-Hamad, Sarah A. Immanuel, Xiao Liu, Yvonne Pamula, Anna Kontos, James A. Martin, Declan John Kennedy, Mark J. Kohler, Alberto Porta, Mathias Baumert

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5 Citations (Scopus)

Abstract

Study objectives: To assess cardiovascular control during sleep in children with sleep-disordered breathing (SDB) and the effect of adenotonsillectomy in comparison to healthy nonsnoring children. Methods: Cardiorespiratory signals obtained from overnight polysomnographic recordings of 28 children with SDB and 34 healthy nonsnoring children were analyzed. We employed an autoregressive closed-loop model with heart period (RR) and pulse transit time (PTT) as outputs and respiration as an external input to obtain estimates of respiratory gain and baroreflex gain. Results: Mean and variability of PTT were increased in children with SDB across all stages of sleep. Low frequency power of RR and PTT were attenuated during non-rapid eye movement (REM) sleep. Baroreflex sensitivity was reduced in children with SDB in stage 2 sleep, while respiratory gain was increased in slow wave sleep. After adenotonsillectomy, these indices normalized in the SDB group attaining values comparable to those of healthy children. Conclusions: In children with mild-to-moderate SDB, vasomotor activity is increased and baroreflex sensitivity decreased during quiet, event-free non-REM sleep. Adenotonsillectomy appears to reverse this effect.

Original languageEnglish
Article numberzsx127
JournalSLEEP
Volume40
Issue number10
DOIs
Publication statusPublished - 2017

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    El-Hamad, F., Immanuel, S. A., Liu, X., Pamula, Y., Kontos, A., Martin, J. A., Kennedy, D. J., Kohler, M. J., Porta, A., & Baumert, M. (2017). Altered nocturnal cardiovascular control in children with sleep-disordered breathing. SLEEP, 40(10), [zsx127]. https://doi.org/10.1093/sleep/zsx127