Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats

Vimal Kapoor, Ranjna Kapoor, John P. Chalmers

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have investigated the effects of microinjection of L-glutamate, D-serine and glycine into the caudal ventrolateral medulla (CVLM) of spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. In SHR the depressor responses to L-glutamate were significantly enhanced compared to WKY rats, while those to the NMDA-glycine site agonists, D-serine and glycine (in the presence of strychnine) were significantly diminished. Depressor responses to NMDA and D-serine could be blocked with 5-fluro-indole-2-carboxylic acid (FICA, an NMDA-glycine site antagonist). In support of our previous findings, the larger responses of NMDA-glutamate site agonists and smaller responses of NMDA-glycine site agonists in SHR, may suggest that SHR have reduced levels of the endogenous glutamate antagonist, kynurenic acid.

Original languageEnglish
Pages (from-to)1409-1412
Number of pages4
JournalNeuroreport
Volume7
Issue number8
DOIs
Publication statusPublished - 31 May 1996
Externally publishedYes

Keywords

  • Blood pressure
  • CVLM
  • D-serine
  • Glutamate
  • Glycine
  • Kynurenic acid
  • Medulla
  • NMDA receptors
  • SHR
  • Strychnine-insensitive modulatory site

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