Ambient, biological, and biological effect monitoring of exposure to polycyclic aromatic hydrocarbons (PAHs)

Berj A. Hatjian; John W. Edwards; John Harrison; Faith M. Williams; Peter G. Blain

doi:10.1016/0378-4274(95)03307-6

Ambient, biological, and biological effect monitoring of exposure to polycyclic aromatic hydrocarbons (PAHs)

Berj A. Hatjian, John W. Edwards, John Harrison, Faith M. Williams, Peter G. Blain

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29 Citations (Scopus)

Abstract

A novel strategy was utilised to assess the risk to health from exposure to polycyclic aromatic hydrocarbons (PAHs). Ambient monitoring was carried out by personal sampling. Urinary thioethers (UTh) and urinary 1-hydroxypyrene (1-HP) were utilised for biological monitoring. Urinary d-glucaric acid (UDGA) and sister chromatid exchange (SCE) in peripheral blood lymphocytes were used as biological effect markers. The population was categorised into exposed and control groups according to the external dose of PAHs. The excretion of 1-HP in the controls over the 3-day period showed a relatively stable baseline, while the exposed showed a significant increase over the same period of time. SCE frequency in the exposed population was significantly different from controls.

Original language	English
Pages (from-to)	271-279
Number of pages	9
Journal	Toxicology Letters
Volume	77
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(95)03307-6
Publication status	Published - May 1995

Keywords

Ambient monitoring
Biological effect monitoring
Biological monitoring
Occupational exposure
PAHs

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title = "Ambient, biological, and biological effect monitoring of exposure to polycyclic aromatic hydrocarbons (PAHs)",

abstract = "A novel strategy was utilised to assess the risk to health from exposure to polycyclic aromatic hydrocarbons (PAHs). Ambient monitoring was carried out by personal sampling. Urinary thioethers (UTh) and urinary 1-hydroxypyrene (1-HP) were utilised for biological monitoring. Urinary d-glucaric acid (UDGA) and sister chromatid exchange (SCE) in peripheral blood lymphocytes were used as biological effect markers. The population was categorised into exposed and control groups according to the external dose of PAHs. The excretion of 1-HP in the controls over the 3-day period showed a relatively stable baseline, while the exposed showed a significant increase over the same period of time. SCE frequency in the exposed population was significantly different from controls.",

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AU - Hatjian, Berj A.

AU - Edwards, John W.

AU - Harrison, John

AU - Williams, Faith M.

AU - Blain, Peter G.

PY - 1995/5

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Ambient, biological, and biological effect monitoring of exposure to polycyclic aromatic hydrocarbons (PAHs)

Abstract

Keywords

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