Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

C. C.T. Smith; D. M. Bowen; N. R. Sims; D. Neary; A. N. Davison

doi:10.1016/0006-8993(83)91131-9

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

C. C.T. Smith, D. M. Bowen, N. R. Sims, D. Neary, A. N. Davison

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and γ-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino acid and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

Original language	English
Pages (from-to)	138-141
Number of pages	4
Journal	Brain Research
Volume	264
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)91131-9
Publication status	Published - 28 Mar 1983
Externally published	Yes

Keywords

Alzheimer's disease
amino acids
human brain
neurotransmitter release
temporal neocortex

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AU - Smith, C. C.T.

AU - Bowen, D. M.

AU - Sims, N. R.

AU - Neary, D.

AU - Davison, A. N.

PY - 1983/3/28

Y1 - 1983/3/28

N2 - Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and γ-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino acid and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

AB - Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and γ-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino acid and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

KW - Alzheimer's disease

KW - amino acids

KW - human brain

KW - neurotransmitter release

KW - temporal neocortex

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Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

Abstract

Keywords

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