Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

C. C.T. Smith, D. M. Bowen, N. R. Sims, D. Neary, A. N. Davison

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and γ-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino acid and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalBrain Research
Volume264
Issue number1
DOIs
Publication statusPublished - 28 Mar 1983
Externally publishedYes

Keywords

  • Alzheimer's disease
  • amino acids
  • human brain
  • neurotransmitter release
  • temporal neocortex

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