Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio: could a drug-induced toxicity be regulating exposure to the offending agent?

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    We read with interest the recent paper of Yamato et al. [1] describing differences in the N-desethyl-amiodarone (DEA) to amiodarone (AMD) ratio in patients with thyroid dysfunction, based on laboratory data, vs. euthyroid patients during AMD treatment.
    Original languageEnglish
    Pages (from-to)1051-1052
    Number of pages2
    JournalEuropean Journal of Clinical Pharmacology
    Issue number8
    Publication statusPublished - 1 Aug 2017


    • Amiodarone
    • Thyroid Dysfunction
    • N-desethyl-amiodarone
    • drug-induced toxicity
    • regulating exposure

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