Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases

Chao Chen, Heqi Gao, Hanlin Ou, Ryan T.K. Kwok, Youhong Tang, Donghui Zheng, Dan Ding

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during the pathological processes. Herein, a peroxynitrite (ONOO-) and environmental pH dual-responsive afterglow luminescent nanoprobe is designed and synthesized. In the presence of ONOO-at physiological pH, the nanoprobes show activated near-infrared afterglow luminescence, whose intensity and lasting time can be highly enhanced by introducing the aggregation-induced emission (AIE) effect with a twisted molecular geometry into the system. In vivo studies using three diseased animal models demonstrate that the nanoprobes can sensitively reveal the development process of acute skin inflammation including infiltration of first arrived neutrophils and acidification initiating time, make a fast and accurate discrimination between allergy and inflammation, and rapidly screen the antitumor drugs capable of inducing immunogenic cell death. This work provides an alternative approach and advanced probes permitting precise disease monitoring in real time.

Original languageEnglish
Pages (from-to)3429-3441
Number of pages13
JournalJournal of the American Chemical Society
Volume144
Issue number8
DOIs
Publication statusPublished - 2 Mar 2022

Keywords

  • Luminescence
  • Molecular structure
  • Pathology

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