An Analysis of the Interactions Between Individual Comorbidities and Their Treatments - Implications for Guidelines and Polypharmacy

Stephen Fitzgerald; Nigel Bean

doi:10.1016/j.jamda.2010.05.008

An Analysis of the Interactions Between Individual Comorbidities and Their Treatments - Implications for Guidelines and Polypharmacy

Stephen Fitzgerald, Nigel Bean

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Background: With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use. Most clinical trials have excluded old, frail individuals and have failed to take into account the effects of outcome interaction. Methods and Results: In this article we provide a mathematical model demonstrating that comorbidities, including old age, interact with therapies, reducing their effectiveness. Conclusion: These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.

Original language	English
Pages (from-to)	475-484
Number of pages	10
Journal	Journal of the American Medical Directors Association
Volume	11
Issue number	7
DOIs	https://doi.org/10.1016/j.jamda.2010.05.008
Publication status	Published - Sept 2010

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10.1016/j.jamda.2010.05.008

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AB - Background: With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use. Most clinical trials have excluded old, frail individuals and have failed to take into account the effects of outcome interaction. Methods and Results: In this article we provide a mathematical model demonstrating that comorbidities, including old age, interact with therapies, reducing their effectiveness. Conclusion: These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.

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An Analysis of the Interactions Between Individual Comorbidities and Their Treatments - Implications for Guidelines and Polypharmacy

Abstract

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