An Analysis of the Interactions Between Individual Comorbidities and Their Treatments - Implications for Guidelines and Polypharmacy

Stephen Fitzgerald, Nigel Bean

    Research output: Contribution to journalArticle

    84 Citations (Scopus)

    Abstract

    Background: With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use. Most clinical trials have excluded old, frail individuals and have failed to take into account the effects of outcome interaction. Methods and Results: In this article we provide a mathematical model demonstrating that comorbidities, including old age, interact with therapies, reducing their effectiveness. Conclusion: These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.

    Original languageEnglish
    Pages (from-to)475-484
    Number of pages10
    JournalJournal of the American Medical Directors Association
    Volume11
    Issue number7
    DOIs
    Publication statusPublished - Sep 2010

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