An assessment of intervention thresholds for high fracture risk in Chile

Enrique Lopez Gavilanez, Imaicela N. Luis, Navarro G. Mario, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Eugene V. McCloskey, John A. Kanis

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Summary: Assessment and treatment pathways using FRAX-based intervention thresholds in Chile can be used to identify patients at high risk of fracture and avoid unnecessary treatment in those at low fracture risk. 

Purpose: The aim of the present study was to explore treatment paths and characteristics of women eligible for treatment in Chile based on major osteoporotic fracture (MOF) probabilities derived from FRAX®. 

Methods: Intervention and assessment thresholds were derived using methods adopted by the National Osteoporosis Guideline Group for FRAX-based guidelines in the UK but based on the epidemiology of fracture and death in Chile. Age-dependent and hybrid assessment and intervention thresholds were applied to 1998 women and 1122 men age 50 years or more drawn from participants in the National Health Survey 2016–2017. 

Results: Approximately 12% of men and women had a prior fragility fracture and would be eligible for treatment for this reason. Using age-dependent thresholds, an additional 2.6% of women (0.3% of men) were eligible for treatment in that MOF probabilities lay above the upper assessment threshold. A BMD test would be recommended in 5% of men and 38% of women. With hybrid thresholds, an additional 13% of women (3.6% of men) were eligible for treatment and BMD recommended in 11% of men and 42% of women. 

Conclusion: The application of hybrid intervention thresholds ameliorates the disparity in fracture probabilities seen with age-dependent thresholds. Probability-based assessment of fracture risk, including the use of the hybrid intervention thresholds for Chile, is expected to help guide decisions about treatment.

Original languageEnglish
Article number11
Number of pages9
JournalArchives of osteoporosis
Issue number1
Publication statusPublished - 17 Dec 2022
Externally publishedYes


  • Fracture risk assessment
  • FRAX
  • Intervention threshold
  • Osteoporosis


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