An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi, Chiara Zanato, Rey Carabeo, Arduino Mangoni, Sergio Dall'Angelo, Matteo Zanda

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

    Original languageEnglish
    Article numberss-2015-n0113-op
    Pages (from-to)3067-3078
    Number of pages12
    JournalSYNTHESIS-STUTTGART
    Volume47
    Issue number19
    DOIs
    Publication statusPublished - 1 Oct 2015

    Keywords

    • antimicrobials
    • cyclization
    • guanidines
    • guanylation
    • lactams

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