An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function

Dusan Matusica, Suse Skeldal, Alex Sykes, Nickless Palstra, Aanchal Sharma, Elizabeth Coulson

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    Background: The mechanism by which the p75 neurotrophin receptor (p75 NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75NTR intracellular domain fragment, p75ICD, but not full-length p75NTR enhanced NGF binding to TrkA and neurite outgrowth. Conclusion: The results suggest that p75ICD causes a conformational change within the extracellular domain of TrkA. Significance: The findings challenge our current understanding of how p75NTR enhances neurotrophic activity.

    Original languageEnglish
    Pages (from-to)11144-11154
    Number of pages11
    JournalJournal of Biological Chemistry
    Volume288
    Issue number16
    DOIs
    Publication statusPublished - 19 Apr 2013

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