An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function

Dusan Matusica; Suse Skeldal; Alex Sykes; Nickless Palstra; Aanchal Sharma; Elizabeth Coulson

doi:10.1074/jbc.M112.436469

An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function

Dusan Matusica, Suse Skeldal, Alex Sykes, Nickless Palstra, Aanchal Sharma, Elizabeth Coulson

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Background: The mechanism by which the p75 neurotrophin receptor (p75 ^NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75^NTR intracellular domain fragment, p75^ICD, but not full-length p75^NTR enhanced NGF binding to TrkA and neurite outgrowth. Conclusion: The results suggest that p75^ICD causes a conformational change within the extracellular domain of TrkA. Significance: The findings challenge our current understanding of how p75^NTR enhances neurotrophic activity.

Original language	English
Pages (from-to)	11144-11154
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M112.436469
Publication status	Published - 19 Apr 2013

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title = "An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function",

abstract = "Background: The mechanism by which the p75 neurotrophin receptor (p75 NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75NTR intracellular domain fragment, p75ICD, but not full-length p75NTR enhanced NGF binding to TrkA and neurite outgrowth. Conclusion: The results suggest that p75ICD causes a conformational change within the extracellular domain of TrkA. Significance: The findings challenge our current understanding of how p75NTR enhances neurotrophic activity.",

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T1 - An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function

AU - Matusica, Dusan

AU - Skeldal, Suse

AU - Sykes, Alex

AU - Palstra, Nickless

AU - Sharma, Aanchal

AU - Coulson, Elizabeth

PY - 2013/4/19

Y1 - 2013/4/19

N2 - Background: The mechanism by which the p75 neurotrophin receptor (p75 NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75NTR intracellular domain fragment, p75ICD, but not full-length p75NTR enhanced NGF binding to TrkA and neurite outgrowth. Conclusion: The results suggest that p75ICD causes a conformational change within the extracellular domain of TrkA. Significance: The findings challenge our current understanding of how p75NTR enhances neurotrophic activity.

AB - Background: The mechanism by which the p75 neurotrophin receptor (p75 NTR) and TrkA interact to enhance neurotrophin signaling is unknown. Results: The p75NTR intracellular domain fragment, p75ICD, but not full-length p75NTR enhanced NGF binding to TrkA and neurite outgrowth. Conclusion: The results suggest that p75ICD causes a conformational change within the extracellular domain of TrkA. Significance: The findings challenge our current understanding of how p75NTR enhances neurotrophic activity.

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DO - 10.1074/jbc.M112.436469

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VL - 288

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EP - 11154

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 16

ER -

An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A (TrkA) receptor function

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